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Article Title |
Author(s) |
Type (Status) |
Available Online |
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Antipsychotic medication and prefrontal cortex activation: A review of neuroimaging findings
DOI: 10.1016/j.euroneuro.2011.12.008
Abstract: Decreased prefrontal activation (hypofrontality) in schizophrenia is thought to underlie negative symptoms and cognitive impairments, and may contribute to poor social outcome. Hypofrontalit...
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Edith J. Liemburg,
Henderikus Knegtering,
Hans C. Klein,
Rudie Kortekaas,
André Aleman
et al.
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Review article
(In Press Corrected Proof)
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03 February 2012 |
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A link between oxytocin and serotonin in humans: Supporting evidence from peripheral markers
DOI: 10.1016/j.euroneuro.2011.12.010
Abstract: Pharmacological studies indicate a functional interaction between the serotonergic and oxytocinergic systems. In particular, some selective serotonin (5-HT) reuptake inhibitors, such as cita...
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Donatella Marazziti,
Stefano Baroni,
Gino Giannaccini,
Laura Betti,
Gabriele Massimetti,
Claudia Carmassi,
Mario Catena-Dell'Osso
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Changes in trend of antipsychotics prescription in patients treated with cholinesterase inhibitors after warnings from Italian Medicines Agency. Results from the EPIFARM-Elderly Project
DOI: 10.1016/j.euroneuro.2011.12.009
Abstract: The objective of the study was to assess the trend of antipsychotic prescription in elderly patients taking cholinesterase inhibitors (ChEIs) from 2002 to 2008 and the changes subsequent to ...
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Carlotta Franchi,
Mauro Tettamanti,
Alessandra Marengoni,
Francesca Bonometti,
Luca Pasina,
Laura Cortesi,
Ida Fortino,
Angela Bortolotti,
Luca Merlino,
Ugo Lucca,
Emma Riva,
Alessandro Nobili
et al.
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Full-length article
(In Press Corrected Proof)
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02 February 2012 |
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Characterization of the neuropsychological phenotype of glycine N-methyltransferase −/− mice and evaluation of its responses to clozapine and sarcosine treatments
DOI: 10.1016/j.euroneuro.2011.12.007
Abstract: Glycine N-methyltransferase (GNMT) affects cellular methylation capacity through regulating the ratio between S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). The product of its ...
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Ching-Ping Yang,
Hsiang-An Wang,
Tung-Hu Tsai,
Angela Fan,
Chia-Lang Hsu,
Chun-Jung Chen,
Chen-Jee Hong,
Yi-Ming Arthur Chen
et al.
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Full-length article
(In Press Corrected Proof)
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24 January 2012 |
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Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: A 27-year longitudinal study
DOI: 10.1016/j.euroneuro.2011.11.002
Abstract: There is an increasing evidence that prenatal and early postnatal stressors have life long impacts on physical and mental health problems. Animal studies have shown that this could include e...
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Linda Booij,
Chawki Benkelfat,
Marco Leyton,
Frank Vitaro,
Paul Gravel,
Mélissa L. Lévesque,
Louise Arseneault,
Mirko Diksic,
Richard E. Tremblay
et al.
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Short communication
(In Press Corrected Proof)
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19 January 2012 |
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Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor
DOI: 10.1016/j.euroneuro.2011.11.006
Abstract: Homer proteins are associated with both dopaminergic and glutamatergic function. In addition, these proteins are implicated in many signal transduction pathways that are also putative target...
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Andrea de Bartolomeis,
Carmine Tomasetti,
Maria Cicale,
Pei-Xiong Yuan,
Husseini K. Manji
et al.
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Full-length article
(In Press Corrected Proof)
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16 January 2012 |
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Differential effects of ADORA2A gene variations in pre-attentive visual sensory memory subprocesses
DOI: 10.1016/j.euroneuro.2011.12.004
Abstract: The ADORA2A gene encodes the adenosine A2A receptor that is highly expressed in the striatum where it plays a role in modulating glutamatergic and dopaminergic transmission. Glutamatergic si...
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Christian Beste,
Ann-Kathrin Stock,
Vanessa Ness,
Jörg T. Epplen,
Larissa Arning
et al.
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Full-length article
(In Press Corrected Proof)
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13 January 2012 |
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Age, sex and NK1 receptors in the human brain — A positron emission tomography study with [11C]GR205171
DOI: 10.1016/j.euroneuro.2011.12.005
Abstract: The substance P/neurokinin 1 (SP/NK1) system has been implicated in the processing of negative affect. Its role seems complex and findings from animal studies have not been easily translated...
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Jonas Engman,
Fredrik Åhs,
Tomas Furmark,
Clas Linnman,
Anna Pissiota,
Lieuwe Appel,
Örjan Frans,
Bengt Långström,
Mats Fredrikson
et al.
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Full-length article
(In Press Corrected Proof)
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06 January 2012 |
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Mapping serotonergic dysfunction in MDMA (ecstasy) users using pharmacological MRI
DOI: 10.1016/j.euroneuro.2011.12.002
Abstract: 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug that has been shown to induce loss of brain serotonin (5-HT) neurons. The purpose of this study was to dete...
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M.L.J. Schouw,
S. Gevers,
M.W.A. Caan,
C.B.L.M. Majoie,
J. Booij,
A.J. Nederveen,
L. Reneman
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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The acute effects of d-amphetamine and d-methamphetamine on ERP components in humans
DOI: 10.1016/j.euroneuro.2011.11.009
Abstract: While a number of behavioural studies have been conducted to investigate the acute effects of amphetamines on tasks of attention and information processing, there is currently a scarcity of ...
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B. Silber,
R. Croft,
D.A. Camfield,
L.A. Downey,
K. Papafotiou,
C. Stough
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Physiological and affective reactivity to a 35% CO2 inhalation challenge in individuals differing in the 5-HTTLPR genotype and trait neuroticism
DOI: 10.1016/j.euroneuro.2011.12.003
Abstract: The inhalation of 35% carbon dioxide (CO2) results in an acute stress response in healthy individuals and may accordingly provide a good paradigm to examine potential vulnerability factors f...
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Ellen Verschoor,
C. Rob Markus
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Acutely applied MDMA enhances long-term potentiation in rat hippocampus involving D1/D5 and 5-HT2 receptors through a polysynaptic mechanism
DOI: 10.1016/j.euroneuro.2011.11.010
Abstract: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a drug of abuse that induces learning and memory deficit. However, there are no experimental data that correlate the behavioral evidence ...
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C. Rozas,
S. Loyola,
G. Ugarte,
M.L. Zeise,
M. Reyes-Parada,
F. Pancetti,
P. Rojas,
B. Morales
et al.
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior
DOI: 10.1016/j.euroneuro.2011.12.001
Abstract: Selective breeding for divergence in locomotion in a novel environment (bHR, bred High-Responder; bLR, bred Low-Responder) correlates with stress-reactivity, spontaneous anxiety-like behavio...
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M.J. García-Fuster,
G.S. Parks,
S.M. Clinton,
S.J. Watson,
H. Akil,
O. Civelli
et al.
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Short communication
(In Press Corrected Proof)
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03 January 2012 |
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A randomised, double-blind, placebo controlled, duloxetine-referenced, fixed-dose study of three dosages of Lu AA21004 in acute treatment of major depressive disorder (MDD)
DOI: 10.1016/j.euroneuro.2011.11.008
Abstract: The efficacy, safety, and tolerability of Lu AA21004 versus placebo, using duloxetine as active reference, in patients with DSM-IV-TR diagnosed major depressive disorder (MDD) were evaluated...
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David S. Baldwin,
Henrik Loft,
Marianne Dragheim
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Predictors of medium and long-term outcome following capsulotomy for obsessive–compulsive disorder: One site may not fit all
DOI: 10.1016/j.euroneuro.2011.11.003
Abstract: Patients with treatment-refractory obsessive–compulsive disorder (OCD) are sometimes considered for surgical interventions. The identification of reliable predictors of outcome following suc...
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Christian Rück,
K. Johan Larsson,
David Mataix-Cols
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Full-length article
(In Press Corrected Proof)
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03 January 2012 |
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Head to head comparisons as an alternative to placebo-controlled trials
DOI: 10.1016/j.euroneuro.2011.11.011
Abstract: Head to head trials have been proposed as an alternative to the ethical and methodological concerns related to placebo-controlled trials. While those studies may be particularly informative ...
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Eduard Vieta,
Nuria Cruz
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Full-length article
(In Press Corrected Proof)
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28 December 2011 |
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Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: Comparison with transient local inactivation
DOI: 10.1016/j.euroneuro.2011.11.004
Abstract: Deep brain stimulation (DBS) has been extensively used in Parkinson's disease and is also currently being investigated in tardive dyskinesia (TD), a movement disorder induced by chronic trea...
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Meaghan C. Creed,
Clement Hamani,
José N. Nobrega
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain
DOI: 10.1016/j.euroneuro.2011.11.005
Abstract: Previous study has documented the long-term effects of the antidepressant trazodone on the serotonin (5-HT) system. The present work examined the impact of sustained trazodone on ventral teg...
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Ramez Ghanbari,
Mostafa El Mansari,
Pierre Blier
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Full-length article
(In Press Corrected Proof)
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12 December 2011 |
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Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment
DOI: 10.1016/j.euroneuro.2011.10.002
Abstract: The preferential dopamine D3-agonist pramipexole (4.25±0.38mg/day) or placebo were added for up to 12weeks to ongoing antipsychotic treatment for 24 adult patients with DSM-IV schizophrenia ...
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James P. Kelleher,
Franca Centorrino,
Nancy A. Huxley,
John A. Bates,
Jennifer Kidwell Drake,
Samy Egli,
Ross J. Baldessarini
et al.
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Short communication
(In Press Corrected Proof)
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12 December 2011 |
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Imaging trait anxiety in high anxiety F344 rats: Focus on the dorsomedial prefrontal cortex
DOI: 10.1016/j.euroneuro.2011.11.001
Abstract: Functional magnetic resonance imaging (fMRI) has become an important method in clinical psychiatry research whereas there are still only few comparable preclinical investigations. Herein, we...
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Eric P. Prinssen,
Laurent B. Nicolas,
Steffen Klein,
Christophe Grundschober,
Cristina Lopez-Lopez,
Melanie S. Keßler,
Andreas Bruns,
Markus von Kienlin,
Joseph G. Wettstein,
Jean-Luc Moreau,
Celine Risterucci
et al.
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Full-length article
(In Press Corrected Proof)
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08 December 2011 |
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Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy
DOI: 10.1016/j.euroneuro.2011.10.003
Abstract: In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was likely the most studied genetic variant as predictor of antidepressant response. Nevertheless results a...
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Stefano Porcelli,
Chiara Fabbri,
Alessandro Serretti
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Review article
(In Press Corrected Proof)
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05 December 2011 |
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A validation of cognitive biomarkers for the early identification of cognitive enhancing agents in schizotypy: A three-center double-blind placebo-controlled study
DOI: 10.1016/j.euroneuro.2011.10.005
Abstract: A number of compounds aimed at improving cognition in schizophrenia have failed to demonstrate efficacy in Phase 2 clinical trials. Translational studies using biomarkers in surrogate popula...
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Ivan Koychev,
Katrina McMullen,
Jane Lees,
Rukiya Dadhiwala,
Lois Grayson,
Charlotte Perry,
Anne Schmechtig,
James Walters,
Kevin J. Craig,
Gerard R. Dawson,
Colin T. Dourish,
Ulrich Ettinger,
Lawrence Wilkinson,
Steven Williams,
John Francis William Deakin,
Emma Barkus
et al.
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Full-length article
(In Press Corrected Proof)
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05 December 2011 |
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Hematological clozapine monitoring with a point-of-care device: A randomized cross-over trial
DOI: 10.1016/j.euroneuro.2011.10.001
Abstract: Clozapine remains the drug of choice for patients with treatment-resistant schizophrenia, who show a response rate of about 50% despite their unresponsiveness to other antipsychotics. Althou...
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Jimmi Nielsen,
Dorrit Thode,
Elsebeth Stenager,
Kristian Øllegaard Andersen,
Ulla Sondrup,
Tine N. Hansen,
Anne Marie Munk,
Signe Lykkegaard,
Annette Gosvig,
Igor Petrov,
Phuong le Quach
et al.
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase
DOI: 10.1016/j.euroneuro.2011.10.004
Abstract: The pharmacokinetics of carbamazepine (CBZ) and its active 10,11-epoxide metabolite (CBZ-E) were evaluated after intravenous and oral administration of 5mg/kg CBZ to rats with hyperlipidemia...
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Young Sun Lee,
Young Woo Kim,
Sang Geon Kim,
Inchul Lee,
Myung Gull Lee,
Hee Eun Kang
et al.
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Full-length article
(In Press Corrected Proof)
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02 December 2011 |
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Severe and anxious depression: Combining definitions of clinical sub-types to identify patients differentially responsive to selective serotonin reuptake inhibitors
DOI: 10.1016/j.euroneuro.2011.09.009
Abstract: Patients with severe major depressive disorder are more likely than those with mild/moderate depression to experience the relative benefits of antidepressant therapy versus placebo. Several ...
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George I. Papakostas,
Hua Fan,
Enrico Tedeschini
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Full-length article
(In Press Corrected Proof)
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18 November 2011 |
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Placebo effect in child and adolescent psychiatric trials
DOI: 10.1016/j.euroneuro.2011.09.007
Abstract: Much literature has been written in the field of child psychiatry regarding the placebo as a tool to test drug efficacy in clinical trials, but quite little regarding the placebo effect itse...
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Mara Parellada,
Carmen Moreno,
Miguel Moreno,
Ana Espliego,
Enrique de Portugal,
Celso Arango
et al.
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Full-length article
(In Press Corrected Proof)
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28 October 2011 |
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VEGF regulates antidepressant effects of lamotrigine
DOI: 10.1016/j.euroneuro.2011.09.010
Abstract: The anticonvulsant drug lamotrigine has been shown to produce strong antidepressant effects in the treatment of bipolar disorder patients. Our previous studies have demonstrated that brain d...
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Rongju Sun,
Nanxin Li,
Tanshi Li
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Full-length article
(In Press Corrected Proof)
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28 October 2011 |
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Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder
DOI: 10.1016/j.euroneuro.2011.09.008
Abstract: Over one half of bipolar patients have been reported to be more prone to either depressive or manic relapses. This study aimed to define profiles of drugs used for maintenance treatment of b...
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Dina Popovic,
Maria Reinares,
Jose Manuel Goikolea,
Caterina Mar Bonnin,
Ana Gonzalez-Pinto,
Eduard Vieta
et al.
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Full-length article
(In Press Corrected Proof)
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17 October 2011 |
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Alteration in RGS2 expression level is associated with changes in haloperidol induced extrapyramidal features in a mutant mouse model
DOI: 10.1016/j.euroneuro.2011.09.006
Abstract: Antipsychotic induced Parkinsonism (AIP) is a common adverse effect of antipsychotic drug treatment among schizophrenia patients. Two previous studies showed association of the rs4606 SNP in...
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Lior Greenbaum,
Tzuri Lifschytz,
Polina Zozulinsky,
Esther C. Broner,
Alexandra Slonimsky,
Yoav Kohn,
Bernard Lerer
et al.
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Short communication
(In Press Corrected Proof)
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10 October 2011 |
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Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels
DOI: 10.1016/j.euroneuro.2011.09.003
Abstract: The second generation antipsychotic drug (SGA) olanzapine has an efficacy to treat schizophrenia, but can cause obesity and type II diabetes mellitus. Cholinergic muscarinic M3 receptors (M3...
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Katrina Weston-Green,
Xu-Feng Huang,
Jiamei Lian,
Chao Deng
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Full-length article
(In Press Corrected Proof)
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10 October 2011 |
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Neuropathological abnormalities of astrocytes, GABAergic neurons, and pyramidal neurons in the dorsolateral prefrontal cortices of patients with major depressive disorder
DOI: 10.1016/j.euroneuro.2011.09.001
Abstract: Human post-mortem brain studies have revealed reduced density and size of neurons and glial cells in the dorsolateral prefrontal cortex (dlPFC) in major depressive disorder (MDD). However, t...
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Dong Hoon Oh,
Hyeon Son,
Sejin Hwang,
Seok Hyeon Kim
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Full-length article
(In Press Corrected Proof)
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03 October 2011 |
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Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life
DOI: 10.1016/j.euroneuro.2011.09.002
Abstract: Schizophrenia is a complex and devastating mental disorder of unknown etiology. Hypofunction of N-methyl-d-aspartate (NMDA) receptors are implicated in the disorder, since phencyclidine (PCP...
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Teresa Marie du Bois,
Kelly Anne Newell,
Xu-Feng Huang
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Full-length article
(In Press Corrected Proof)
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03 October 2011 |
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The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating
DOI: 10.1016/j.euroneuro.2011.09.004
Abstract: Converging evidence from preclinical and clinical studies suggest that oxytocin has therapeutic potential for schizophrenia and other neuropsychiatric disorders. Prepulse inhibition of the s...
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David Feifel,
Paul D. Shilling,
Annabelle M. Belcher
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Short communication
(In Press Corrected Proof)
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03 October 2011 |
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The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder — A European Multicenter Study
DOI: 10.1016/j.euroneuro.2011.08.007
Abstract: Many association studies have reported associations between the catechol-O-methyltransferase (COMT) gene and psychiatric disorders including major depression (MDD). The COMT gene has further...
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A. Schosser,
R. Calati,
A. Serretti,
I. Massat,
N. A. Kocabas,
K. Papageorgiou,
S. Linotte,
J. Mendlewicz,
D. Souery,
J. Zohar,
A. Juven-Wetzler,
S. Montgomery,
S. Kasper
et al.
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Full-length article
(In Press Corrected Proof)
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23 September 2011 |
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The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression
DOI: 10.1016/j.euroneuro.2011.08.006
Abstract: Transforming growth factor-β1 (TGF-β1) is a neurotrophic factor that exerts neuroprotective effects against β-amyloid-induced neurodegeneration. Recently, a specific impairment of the TGF-β1...
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Filippo Caraci,
Paolo Bosco,
Maria Signorelli,
Rosario S. Spada,
Filomena I. Cosentino,
Giuseppe Toscano,
Cinzia Bonforte,
Stefano Muratore,
Giuseppina Prestianni,
Simonetta Panerai,
Maria Concetta Giambirtone,
Eleonora Gulotta,
Carmelo Romano,
Maria Grazia Salluzzo,
Ferdinando Nicoletti,
Agata Copani,
Filippo Drago,
Eugenio Aguglia,
Raffaele Ferri
et al.
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Full-length article
(In Press Corrected Proof)
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19 September 2011 |
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New insights on the consequences of biotransformation processes on the distribution and pharmacodynamic profiles of some neuropsychotropic drugs
DOI: 10.1016/j.euroneuro.2011.08.004
Abstract: The metabolic processes frequently trigger highly complex pharmacokinetic (PK) and pharmacodynamic (PD) characteristics for the coexisting entities, parent drug and its active or inactive me...
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Victor A. Voicu,
Jose de Leon,
Andrei Valentin Medvedovici,
Flavian Ştefan Rădulescu,
Dalia Simona Miron
et al.
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Full-length article
(In Press Corrected Proof)
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15 September 2011 |
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Evaluation of sigma (σ) receptors in the antidepressant-like effects of ketamine in vitro and in vivo
DOI: 10.1016/j.euroneuro.2011.08.002
Abstract: Ketamine is an NMDA antagonist and dissociative anesthetic that has been shown to display rapid acting and prolonged antidepressant activity in small-scale human clinical trials. Ketamine al...
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Matthew J. Robson,
Meenal Elliott,
Michael J. Seminerio,
Rae R. Matsumoto
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Full-length article
(In Press Corrected Proof)
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13 September 2011 |
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Prenatal exposure to bacterial endotoxin reduces the number of GAD67- and reelin-immunoreactive neurons in the hippocampus of rat offspring
DOI: 10.1016/j.euroneuro.2011.08.001
Abstract: Epidemiological studies implicate prenatal infection as a risk factor for the development of schizophrenia and autism. Subjects with schizophrenia and autism are reported to exhibit reduced ...
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Dominique Nouel,
Melissa Burt,
Ying Zhang,
Louise Harvey,
Patricia Boksa
et al.
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Full-length article
(In Press Corrected Proof)
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02 September 2011 |
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Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats
DOI: 10.1016/j.euroneuro.2011.07.015
Abstract: The novel triple monoamine inhibitor tesofensine blocks dopamine, serotonin and norepinephrine re-uptake and is a promising candidate for the treatment of obesity. Obesity is associated with...
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Elsmarieke van de Giessen,
Kora de Bruin,
Susanne E. la Fleur,
Wim van den Brink,
Jan Booij
et al.
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Full-length article
(In Press Corrected Proof)
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02 September 2011 |
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Efficacy of a targeted cognitive–behavioral treatment program for cannabis use disorders (CANDIS*)
DOI: 10.1016/j.euroneuro.2011.07.014
Abstract: Aims: To examine the efficacy, 3- and 6-month follow-up effects of a psychological treatment for older adolescents and adults with DSM-IV cannabis use disorders. The program was tailored to ...
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E. Hoch,
R. Noack,
J. Henker,
A. Pixa,
M. Höfler,
S. Behrendt,
G. Bühringer,
H.-U. Wittchen
et al.
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Full-length article
(In Press Corrected Proof)
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25 August 2011 |