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European Neuropsychopharmacology
Article in Press
Characterization of the neuropsychological phenotype of glycine N-methyltransferase
−/− mice and evaluation of its responses to clozapine and sarcosine treatments
References
- . Molecular cloning and tissue distribution of rat sarcosine dehydrogenase. Eur. J. Biochem. 1998;257:556–561
- . Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/− knock-outs compared with wild-type mice. J. Neurosci. 2007;27:4519–4529
- . Procognitive and antipsychotic efficacy of glycine transport 1 inhibitors (GlyT1) in acute and neurodevelopmental models of schizophrenia: latent inhibition studies in the rat. Psychopharmacology (Berl.). 2009;202:385–396
- . The enzymic N-methylation of glycine. Biochem. Biophys. Res. Commun. 1960;3:259–263
- . Comprehensive sequence analysis of the 182 predicted open reading frames of yeast chromosome III. Protein Sci. 1992;1:1677–1690
- . The glycine transporter-1 inhibitor SSR103800 displays a selective and specific antipsychotic-like profile in normal and transgenic mice. Neuropsychopharmacology. 2010;35:416–427
- . Sensorimotor gating and schizophrenia. Human and animal model studies. Arch. Gen. Psychiatry. 1990;47:181–188
- . Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl.). 2001;156:234–258
- . Inbred mouse strains differ in the regulation of startle and prepulse inhibition of the startle response. Behav. Neurosci. 1997;111:1353–1360
- . Hepatic encephalopathy. Alcohol Res. Health. 2003;27:240–246
- . Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene. Genomics. 2000;66:43–47
- . Type III neuregulin-1 is required for normal sensorimotor gating, memory-related behaviors, and corticostriatal circuit components. J. Neurosci. 2008;28:6872–6883
- . Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Proc. Natl. Acad. Sci. U. S. A. 1984;81:3631–3634
- . Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell. Mol. Neurobiol. 2006;26:365–384
- . The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 2005;29:571–625
- . Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat. Genet. 2004;36:131–137
- . Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat. Neurosci. 2010;13:423–430
- . Schizophrenia. N. Engl. J. Med. 2003;349:1738–1749
- . The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry. 2003;160:636–645
- . Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat. Med. 2006;12:824–828
- . Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology. Biol. Psychiatry. 2006;60:132–140
- . Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch. Gen. Psychiatry. 2003;60:572–576
- . Evidence of missense mutations on the neuregulin 1 gene affecting function of prepulse inhibition. Biol. Psychiatry. 2008;63:17–23
- . Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 2000;26:443–455
- . Haplotypes, loss of heterozygosity, and expression levels of glycine N-methyltransferase in prostate cancer. Clin. Cancer Res. 2007;13:1412–1420
- . Animal models of schizophrenia. Br. J. Pharmacol. 2011;164:1162–1194
- . Signaling pathways in schizophrenia: emerging targets and therapeutic strategies. Trends Pharmacol. Sci. 2010;31:381–390
- . Competing methyltransferase systems. J. Biol. Chem. 1972;247:4248–4252
- . Regulatory factors associated with synthesis of the osmolyte glycine betaine in the halophilic methanoarchaeon Methanohalophilus portucalensis. Appl. Environ. Microbiol. 1999;65:828–833
- . Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. Arch. Gen. Psychiatry. 2005;62:1196–1204
- . Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia. Biol. Psychiatry. 2006;60:645–649
- . A randomized, double-blind, placebo-controlled comparison study of sarcosine (N-methylglycine) and D-serine add-on treatment for schizophrenia. Int. J. Neuropsychopharmacol. 2010;13:451–460
- . Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat. Neurosci. 2010;13:1137–1143
- . Catching up on schizophrenia: natural history and neurobiology. Neuron. 2000;28:325–334
- . Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: implications of the gender disparity in liver cancer susceptibility. Int. J. Cancer. 2009;124:816–826
- . Glycine N-methyltransferase−/− mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007;46:1413–1425
- . Application of a liquid chromatography/tandem mass spectrometry method to pharmacokinetic study of mangiferin in rats. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2010;878:3345–3350
- . Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation. J. Hepatol. 2009;51:528–534
- . Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 2008;47:1191–1199
- . Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. Nat. Rev. Neurosci. 2008;9:437–452
- . Neuropsychiatric dysfunction in patients with chronic hepatitis and liver cirrhosis. Hepatol. Res. 2008;38:1069–1075
- . A genome-wide investigation of SNPs and CNVs in schizophrenia. PLoS Genet. 2009;5:e1000373
- . Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers. Comp. Biochem. Physiol. B. 1993;106:601–611
- . Inbred strain differences in prepulse inhibition of the mouse startle response. Psychopharmacology (Berl.). 1997;132:169–180
- . Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms. Mol. Psychiatry. 2007;12:946–957
- . Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade. Proc. Natl. Acad. Sci. U. S. A. 2010;107:5622–5627
- . The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl.). 1985;85:367–370
- . Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry. 2003;60:1187–1192
- . Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease. J. Neurol. Neurosurg. Psychiatry. 1995;58:192–200
- . AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families. Biol. Psychiatry. 2008;63:449–457
- . Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol. Psychiatry. 2004;55:452–456
- . Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. Cancer Res. 2003;63:647–654
- . Control of synaptic strength, a novel function of Akt. Neuron. 2003;38:915–928
- . The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol. Cell. Biol. 2003;23:1546–1557
- . Acoustic startle and prepulse inhibition in 40 inbred strains of mice. Behav. Neurosci. 2003;117:716–727
- . The effects of glycine transporter I inhibitor, N-methylglycine (sarcosine), on ketamine-induced alterations in sensorimotor gating and regional brain c-Fos expression in rats. Neurosci. Lett. 2010;469:127–130
- Yen, C.H., Lu, Y.C., Li, Y.C., Lee, M.C., Chen, C.Y., Cheng, M.Y., Hung, S.F., Chen, K.F., Cheng, A.L., Liao, L.Y., Lee, Y.H., Chen, Y.M., in press. Functional Characterization of GNMT and its Interacting Protein-DEPTOR in Hepatocellular Carcinoma. Mol. Med. (Electronic publication ahead of print). doi:10.2119/molmed.2011.00331.
- . Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver. Proc. Natl. Acad. Sci. U. S. A. 1994;91:210–214
- . The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex. Neurosci. Lett. 2008;434:23–28
- . BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat. Neurosci. 2007;10:702–711
☆ Competing interests: The authors declared that there was no conflict of interests.
PII: S0924-977X(11)00334-8
doi: 10.1016/j.euroneuro.2011.12.007
© 2011 Elsevier B.V. and ECNP. All rights reserved.
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European Neuropsychopharmacology
Article in Press
