European Neuropsychopharmacology
Volume 21, Issue 9 , Pages 655-679 , September 2011

The size and burden of mental disorders and other disorders of the brain in Europe 2010

  • H.U. Wittchen

      Affiliations

    • Institute of Clinical Psychology and Psychotherapy, Center of Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany
    • Corresponding Author InformationCorresponding author at: Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Chemnitzer Str. 46; D-01187 Dresden, Germany. Tel.: +49 351 463 36985x36983; fax: +49 351 463 36984.
    • Equally shared first authorship.
  • ,
  • F. Jacobi

      Affiliations

    • Institute of Clinical Psychology and Psychotherapy, Center of Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany
    • Equally shared first authorship.
    • Also affiliated with Psychologische Hochschule Berlin, Germany.
  • ,
  • J. Rehm

      Affiliations

    • Institute of Clinical Psychology and Psychotherapy, Center of Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany
    • Centre for Addiction and Mental Health, Toronto, Canada
  • ,
  • A. Gustavsson

      Affiliations

    • i3 Innovus, Stockholm, Sweden
  • ,
  • M. Svensson

      Affiliations

    • Department of Economics and Statistics, Karlstad University, Sweden
  • ,
  • B. Jönsson

      Affiliations

    • Department of Economics, Stockholm School of Economics, Sweden
  • ,
  • J. Olesen

      Affiliations

    • Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
  • ,
  • C. Allgulander

      Affiliations

    • Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
  • ,
  • J. Alonso

      Affiliations

    • Health Services Research Unit, IMIM (Hospital del Mar Research Institute), Barcelona, Spain
  • ,
  • C. Faravelli

      Affiliations

    • Department of Neurology and Psychiatry, University of Florence, Florence, Italy
  • ,
  • L. Fratiglioni

      Affiliations

    • Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
  • ,
  • P. Jennum

      Affiliations

    • Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
  • ,
  • R. Lieb

      Affiliations

    • Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Basel, Switzerland
  • ,
  • A. Maercker

      Affiliations

    • Department of Psychology, Psychopathology and Clinical Intervention, University of Zürich, Zurich, Switzerland
  • ,
  • J. van Os

      Affiliations

    • Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
  • ,
  • M. Preisig

      Affiliations

    • Department of Psychiatry, University Hospital Center and University of Lausanne, Lausanne, Switzerland
  • ,
  • L. Salvador-Carulla

      Affiliations

    • UNIVIDD (Intellectual Disability-Developmental Disorders Research Unit), Villablanca Foundation, Reus, Spain
  • ,
  • R. Simon

      Affiliations

    • European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal
  • ,
  • H.-C. Steinhausen

      Affiliations

    • Clinical Psychology and Epidemiology, Department of Psychology, University of Basel, Basel, Switzerland
    • Child and Adolescent Psychiatry, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aarhus, Denmark
    • Department of Child and Adolescent Psychiatry, University of Zurich, Zürich, Switzerland

References5 

  1. Abela A, Mamo J, Aquilina C, et al. Estimated prevalence of dementia in the Maltese Islands. Malta Med. J. 2007;19:23
  2. Alonso J, Kessler R. Prevalence and treatment of mental disorders in Germany: results from the European study of the epidemiology of mental disorders (ESEMeD) survey. In: Kessler , Üstun  editor. The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders. New York: Cambridge University Press; 2008;p. 331–345
  3. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 3rd ed.. Washington, DC: American Psychiatric Association; 1980;
  4. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. (rev.) third ed.. Washington, DC: American Psychiatric Association; 1987;
  5. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  6. Andersen K. Prevalence of very mild to severe dementia in Denmark. Acta Neurol. Scand. 1997;96:82–87
  7. Andlin-Sobocki P, Olesen J, Wittchen H-U, Jönsson B. Cost of disorders of the brain in Europe. Eur. J. Neurol. 2005;12:1–27
  8. *Angst J, Gamma A, Gastpar M, Lépine J-P, Mendlewicz J, Tylee A. Gender differences in depression. Eur. Arch. Psy. Clin. N. 2002;252:201–209
  9. *Angst J, Gamma A, Endrass J, Goodwin R, Ajdacic V, Eich D, et al. Obsessive–compulsive severity spectrum in the community: prevalence, comorbidity, and course. Eur. Arch. Psy. Clin. N. 2004;254:156–164
  10. *Ansseau M. Èpidémiologie des troubles Psychiatiques dans la Province de Luxembourg. Brochure editée par la plate-forme de concertation psychiatrique de la Provence de Luxembourg. 1999;
  11. Arbabzadeh-Bouchez S, Gasquet I, Kovess-Masfety V, Negre-Pages L, Lépine JP. The prevalence of mental disorders and service use in France: results from a National Survey 2001–2002. In: Kessler , Üstun  editor. The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders. New York: Cambridge University Press; 2008;p. 305–330
  12. *Arnarson EÖ, Gudmundsdottir A, Boyle GJ. Six-month prevalence of phobic symptoms in Iceland: an epidemiological postal survey. J. Clin. Psychol. 1998;54:257–265
  13. *Ayuso-Mateos JL. Depressive disorders in Europe: prevalence figures from the ODIN study. Br. J. Psychiatry. 2001;179:308–316
  14. *Baruffol E. Anxiety, depression, somatization and alcohol abuse. Prevalence rates in a general Belgian community sample. Acta Psychiatr. Belg. 1993;93:136–153
  15. Battaglia A, Dubini A, Mannheimer R, Pancheri P. Depression in the Italian community: epidemiology and socio-economic implications. Int. Clin. Psychopharmacol. 2004;19:135–142
  16. Baumgärtel A, Wolraich ML, Dietric M. Comparison of diagnostic criteria for attention deficit disorders in a German elementary school sample. J. Am. Acad. Child Adolesc. Psychiatry. 1995;34:629–638
  17. Bdzan LB, Turczyński J, Szabert K. Prevalence of dementia in a rural population [Article in Polish]. Psychiatr. Pol. 2007;41(2):181–188(Mar–Apr)
  18. *Becker ES, Türke V, Neumer S, Soeder U, Krause P, Margraf J. Incidence and prevalence rates of mental disorders in a community sample of young women: results of the “Dresden Study”. In:  Manz R,  Kirch W editor. Public Health Research and Practice: Report of the Public Health Reserach Association Saxony II. Regensburg: Roederer; 2000;p. 259–291
  19. Beesdo K, Höfler M, Leibenluft E, Lieb R, Bauer M, Pfennig A. Mood episodes and mood disorders: Patterns of incidence and conversion in the first three decades of life. Bipolar Disorders. 2009;11:637–649
  20. Beesdo K, Pine DS, Lieb R, Wittchen HU. Incidence and risk patterns of anxiety and depressive disorders and categorization of Generalized Anxiety Disorder. Arch. Gen. Psychiatry. 2010;67(1):47–57
  21. Berr C, Wancata J, Ritchie K. Prevalence of dementia in the elderly in Europe. Eur. Neuropsychopharmacol. 2005;15(4):463–471
  22. Berwick DM, Murphy JM, Goldman PA. Performance of a five item mental health screening test. Med. Care. 1991;29:169–176
  23. *Bijl RV, Ravelli A, van Zessen G. Prevalence of psychiatric disorder in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Soc. Psych. Psych. Epid. 1998;33:587–595
  24. Bijl RV, Ravelli A. Current and residual functional disability associated with psychopathology: findings from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Psychol. Med. 2000;30:657–668
  25. Bijl RV, Ravelli A. Psychiatric morbidity, service use, and need for care in the general population: results of The Netherlands Mental Health Survey and Incidence Study. Am. J. Public Health. 2000;90:602–607
  26. Bijl RV, de Graaf R, Hiripi E, Kessler RC, Kohn R, Offord DR, et al. The prevalence of treated and untreated mental disorders in five countries. Health Aff. 2003;22:122–133
  27. Börjesson-Hanson A, Edin E, Gislason T, Skoog I. The prevalence of dementia in 95 year olds. Neurology. 2004;63(12):2436–2438Dec 28
  28. Brayne C. Incidence of dementia in England and Wales: the MRC Cognitive Function and Ageing Study. Alzheimer Dis. Assoc. Disord. 2006;20(3 Suppl. 2):S47–S51Jul–Sep
  29. Bruffaerts R, Bonnewyn A, Demyttenaire K. Metal Health in Belgium: Current Situation and future perspectives. In:  Kessler R,  Üstün B editor. The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders. New York: Cambridge University Press; 2008;p. 279–304
  30. Brugha TS, McManus S, Bankart J, Scott F, Purdon S, Smith J, et al. Epidemiology of autism spectrum disorders in adults in the community in England. Arch. Gen. Psychiatry. 2011;68:459–466
  31. Campenhausen S, Bornschein B, Wick R, Bötzel K, Sampaio C, Poewe W, et al. Prevalence and incidence of Parkinson's disease in Europe. Eur. Neuropsychopharmacol. 2005;15(4):473–490
  32. Coid J, Yang M, Tyrer P. Prevalence and correlates of personality disorder in Great Britain. Br. J. Psychiatry. 2006;188:423–431
  33. Collins PY, Patel V, Joestl SS, et al. Grand challenges in global mental health. Nature. 2011;475(7354):27.30
  34. Corrigan P. How stigma interferes with mental health care. Am. Psychol. 2004;59(7):614–625
  35. Darves-Bornoz JM, Alonso J, de Girolamo G, de Graaf R, Haro JM, Kovess-Masfety V, et al. Main traumatic events in Europe: PTSD in the European study of the epidemiology of mental disorders survey. J. Trauma. Stress. 2008;21:455–462
  36. de Girolamo G, Polidori G, Morosini P, Scarpino V, Reda V, Serra G, et al. Prevalence of common mental disorders in Italy: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD). Soc. Psychiatry Psychiatr. Epidemiol. 2006;41:853–861
  37. de Girolamo G, Morosini P, Gigantesco A, Delmonte S, Kessler R. The prevalence of mental disorders and service use in Italy: results from the National Health Survey 2001–2003. In:  Kessler L,  Üstun M editor. New York: Cambridge University Press; 2008;p. 364–387
  38. de Graaf R, Ormel J, ten Have M, Burger H, Buist-Bouwman M. Mental Disorders and Service Use in the Netherlands: Results from the European Study of the Epidemiology of Mental Disorders (ESEMeD). In:  Kessler L,  Üstun M editor. The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders. New York: Cambridge University Press; 2008;p. 388–405
  39. de Graaf R, ten Have M, van Dorsselaer S. The Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2): design and methods. Int. J. Methods Psychiatr. Res. 2010;193:125–141
  40. de Graaf R, Ten Have M, van Gool C, van Dorsselaer S. Prevalence of mental disorders and trends from 1996 to 2009. Results from the Netherlands Mental Health Survey and Incidence Study-2. Soc. Psychiatry Psychiatr. Epidemiol. 2011;
  41. De Ronchi D, Berardi D, Menchetti M, et al. Occurrence of cognitive impairment and dementia after the age of 60: a population-based study from Northern Italy. Dement. Geriatr. Cogn. Disord. 2005;19(2–3):97–105
  42. de Vries GJ, Olff M. The lifetime prevalence of traumatic events and posttraumatic stress disorder in the Netherlands. J. Trauma. Stress. 2009;22:259–267
  43. Desai AV, Cherkas LF, Spector TD, Williams AJ. Genetic influences in self-reported symptoms of obstructive sleep apnoea and restless legs: a twin study. Twin Res. 2004;7(6):589–595(Dec)
  44. Döpfner M, Görtz-Dorten A, Lehmkuhl G. Diagnostik-System für psychische Störungen nach ICD-10 und DSM-IV für Kinder und Jugendliche — II. Göttingen: Testzentrale; 2008;
  45. Döpfner M, Breuer D, Wille N, Erhart M, Ravens-Sieberer U. How often do children meet ICD-10/DSM-IV criteria of attention deficit-/hyperactivity disorder and hyperkinetic disorder? Parent-based prevalence rates in a national sample — results of the BELLA study. Eur. Child Adolesc. Psychiatry. 2008;17(Suppl. 1):59–70
  46. *Dubini A, Mannheimer R, Pancheri P. Depression in the community: results of the first Italian survey. Int. Clin. Psychopharmacol. 2001;16:49–53
  47. Durkin M. The epidemiology of developmental disabilities in low-income countries. Ment. Retard. Dev. Disabil. Res. Rev. 2002;8:206–211
  48. EMCDDA . Annual Report 2010, the State of the Drugs Problem in Europe. Publications Office of the European Union; 2010;
  49. ESEMeD/MHEDEA 2000 Investigators . The European Study of the Epidemiology of mental Disorders (ESEMeD/MHEDEA 2000). Project: rationale and methods. Int. J. Methods Psychiatr. Res. 2002;11:55–67
  50. *ESEMeD/MHEDEA 2000 Investigators . Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr. Scand. 2004;109(suppl. 1):21–27
  51. ESEMeD/MHEDEA 2000 investigators . Disability and quality of life impact of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr. Scand. 109. Suppl. 1; 2004;
  52. ESEMeD/MHEDEA 2000 Investigators . Use of mental health services in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr. Scand. 2004;109(Suppl. 1):47–54
  53. Esser G, Schmidt H, Woerner W. Epidemiology and course of psychiatric disorders in school age children: results of a longitudinal study. J. Child Psychol. Psychiatry. 1990;31:243–263
  54. *Faravelli C, Abrardi L, Bartolozzi D, Cecchi C, Cosci F, D'Adamo D, et al. The Sesto Fiorentino Study: point and one year prevalences of psychiatric disorders in an Italian community sample using clinical interviewers. Psychother. Psychosom. 2004;73:226–234
  55. Ferini-Strambi L, Zucconi M, Palazzi S, Castronovo V, Oldani A, Della MG, et al. Snoring and nocturnal oxygen desaturations in an Italian middle-aged male population. Epidemiologic study with an ambulatory device. Chest. 1994;105(6):1759–1764Jun
  56. Ferini-Strambi L, Zucconi M, Castronovo V, Garancini P, Oldani A, Smirne S. Snoring & sleep apnea: a population study in Italian women. Sleep. 1999;22(7):859–864Nov 1
  57. First MB, Gibbon M, Spitzer RL, et al. Structured Clinical Interviews for DSM-IV Axis-II Personality Disorders. Washington, DC: American Psychiatric Press; 1997;
  58. Florescu S, Moldovan M, Mihaescu-Pintia C, Ciutan M, Sorel GE. The Mental Health Study. Romania 2007. Prevalence, severity, and treatment of 12-month DSM-IV disorders. Manag. Health. 2009;13:23–31
  59. Fombonne E. Epidemiology of pervasive developmental disorders. Pediatr. Res. 2009;65:591–598
  60. Ford T, Goodman R, Meltzer H. The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders. J. Am. Acad. Child Adolesc. Psychiatry. 2003;42:1203–1211
  61. Fryers T, Brugha T, Morgan Z, Smith J, Hill T, Carta M, et al. Prevalence of psychiatric disorder in Europe: the potential and reality of meta-analysis. Soc. Psychiatry Psychiatr. Epidemiol. 2004;39:899–905
  62. Gascón-Bayarri J, Reñé R, Del Barrio JL, et al. Prevalence of dementia subtypes in El Prat de Llobregat, Catalonia, Spain: the PRATICON study. Neuroepidemiology. 2007;28(4):224–234
  63. Ghorayeb I, Loundou A, Auquier P, Dauvilliers Y, Bioulac B, Tison F. A nationwide survey of excessive daytime sleepiness in Parkinson's disease in France. Mov Disord. 2007;22(11):1567–1572Aug 15
  64. Gislason T, Almqvist M, Eriksson G, Taube A, Boman G. Prevalence of sleep apnea syndrome among Swedish men — an epidemiological study. J. Clin. Epidemiol. 1988;41(6):571–576
  65. Goldberg DP, Hillier VF. A scaled version of the general health questionnaire. Psychol. Med. 1979;9:139–145
  66. Goldberg D, Huxley P. Mental illness in the community: the pathway to psychiatric care. London: Tavistock; 1980;
  67. Gomez-Beneyeto M, Bonet A, Catala MA. Prevalence of mental disorders among children in Valencia, Spain. Acta Psychiatr. Scand. 1994;89:352–357
  68. Goncalves DC, Pachana NA, Byrne GJ. Prevalence and correlates of generalized anxiety disorder among older adults in the Australian National Survey of Mental Health and Well-Being. J. Affect. Disord. 2011;132:223–230
  69. Gostynski M, Ajdacic-Gross V, Gutzwiller F, et al. Prevalence of dementia in the City of Zurich. Soz. Praventivmed. 2002;47(5):330–335(German)
  70. Grant BF, Hasin DS, Stinson FS, et al. Prevalence, correlates, and disability of personality disorders in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J. Clin. Psychiatry. 2004;65:948–958
  71. Grant BF, Chou SP, Goldstein RB, et al. Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. J. Clin. Psychiatry. 2008;69(4):533–545
  72. Greenberg PE, Kessler RC, Nells TL, Finkelstein SN, Berndt ER. Depression in the workplace: an economic perspective. In:  Feighner JP,  Boyer WF editor. Selective Serotonin Reuptakers: Advances in Basic Research and Clinical Practice. New York: Wiley; 1996;
  73. Greenberg PE, Sisitsky T, Kessler RC, Finkelstein SN, Berndt ER, Davidson JRT, et al. The economic burden of anxiety disorders in the 1990s. J. Clin. Psychiatry. 1999;60:427–435
  74. *Hällström T, Damström T, Thakker K, Forsell Y, Lundber I, Tinghög P. The PART Study. A population based study of mental health in the Stockholm county: study design. In: Phase. 1:Stockholm: Samhällsmedicin; 2003;(1998–2001)
  75. Hansen ABG, Hvidtfeldt UA, Gronbaek M, Backer U, Nielsen AS, Tolstrup JS. The number of persons with alcohol problems in the Danish population. Scand. J. Public Health. 2011;39:128–136
  76. Hapke U, Scumann A, Rumpf HU, John U, Meyer C. Post-traumatic stress disorder. The role of trauma, pre-exicting psychiatric disorders, and gender. Eur. Arch. Psychiatry Clin. Neurosci. 2006;256:299–306
  77. Harma M, Tenkanen L, Sjoblom T, Alikoski T, Heinsalmi P. Combined effects of shift work and life-style on the prevalence of insomnia, sleep deprivation and daytime sleepiness. Scand J Work Environ Health. 1998;24(4):300–307Aug
  78. Haro JM, Arbabzadeh-Bouchez S, Brugha TS, de Girolamo D, Guyer ME, jin, R, et al. Concordance of the Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) with standardized clinical assessments in the WHO World Mental Health Surveys. In: Kessler , Üstun  editor. The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders. New York: Cambridge University Press; 2008;p. 114–134
  79. Heier MS, Evsiukova T, Wilson J, Abdelnoor M, Hublin C, Ervik S. Prevalence of narcolepsy with cataplexy in Norway. Acta Neurol Scand. 2009;120(4):276–280Oct
  80. Helmer C, Pérès K, Letenneur L, et al. Dementia in subjects aged 75years or over within the PAQUID cohort: prevalence and burden by severity. Dement. Geriatr. Cogn. Disord. 2006;22(1):87–94
  81. Huang Y, Kotov R, de Girolamo G, et al. DSM-IV personality disorders in the WHO World Mental Health Surveys. Br. J. Psychiatry. 2009;195:46–53
  82. Hublin C, Kaprio J, Partinen M, Koskenvuo M, Heikkila K, Koskimies S, et al. The prevalence of narcolepsy: an epidemiological study of the Finnish Twin Cohort. Ann Neurol. 1994;35(6):709–716Jun
  83. Jacobi F, Wittchen H-U, Holting C, Sommer S, Lieb R, Höfler M, et al. Estimating the prevalence of mental and somatic disorders in the community: aims and methods of the German National Health Interview and Examination Survey. Int. J. Method. Psych. 2002;11:1–18
  84. *Jacobi F, Wittchen H-U, Hölting C, Höfler M, Müller N, Pfister H, et al. Prevalence, comorbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS). Psychol. Med. 2004;34:597–611
  85. Jacobi F, Klose M, Wittchen H-U. Psychische Störungen in der Allgemeinbevölkerung: Inanspruchnahme von Gesundheitsleistungen und Ausfalltage. [Mental disorders in the community: Health care utilization and disability days]. Bundesgesundheitsblatt Gesundh. Forsch Gesundh.Schutz. 2004;47:736–744
  86. *Jenkins R, Lewis G, Bebbington P, Brugha T, Farrell M, Gill B, et al. The National Psychiatric Morbidity surveys of Great Britain — initial findings from the household survey. Psychol. Med. 1997;27:775–789
  87. Jennum P, Sjol A. Snoring, sleep apnoea and cardiovascular risk factors: the MONICA II study. Int J Epidemiol. 1993;22(3):439–444Jun
  88. In: Kessler , Üstün  editor. The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders. New York: Cambridge University Press; 2008;
  89. Kessler RC, Andrews G, Mroczek D, Üstün TB, Wittchen H-U. The World Health Organization Composite International Diagnostic Interview Short-Form (CIDI-SF). Int. J. Method. Psych. 1998;74:171–185
  90. Kessler RC, Cox BJ, Green JG, et al. The effects of latent variables in the development of comorbidity among common mental disorders. Depression and Anxiety. 2011;28(1):29–39
  91. Kessler RC, Frank RG. The impact of psychiatric disorders on work loss days. Psychol. Med. 1997;27:861–873
  92. Kessler RC, Merikangas KR, Berglund P, Eaton WW, Koretz DS, Walters EE. Mild disorders should not be eliminated from the DSM-V. Arch. Gen. Psychiatry. 2003;60:1117–1122
  93. Klin A, Lemish D. Mental disorders stigma in the media: review of studies on production, content, and influences. J. Health Commun. 2008;13:434–449
  94. Klutmann M, Winkels W, Simon H. Incidence and probable detection of sleep apnea in a hospital internal medicine department. Pneumologie. 1995;49(Suppl. 1):142–144Mar
  95. Knapp M, McDaid D, Amaddeo F, Constantopoulos A, Oliveira M, Salvador-Carulla L, et al. Financing mental health care in Europe. J. Ment. Health. 2007;1616(2):167–180C:\SPS\Documents and Settings\Usuario\Documents and Settings\Luis\Escritorio\usbSept107\title~content=t713432595~db=all~tab=issueslist~branches=16
  96. Knauper B, Wittchen HU. Diagnosing major depression in the elderly — evidence for response bias in standardized diagnostic interviews. J. Psychiatr. Res. 1994;28:147–164
  97. *Kringlen E, Torgersen S, Cramer V. A Norwegian Psychiatric Epidemiological Study. Am. J. Psychiatry. 2001;158:1091–1098
  98. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J. Gen. Intern. Med. 2001;16:606–613
  99. Kroes M, Kalff AC, Kessels AGH, Stevaert J, Feron F, van Sommeren A, et al. Child psychiatric diagnoses in a population of Dutch schoolchildren aged 6 to 8years. J. Am. Acad. Child Adolesc. Psychiatry. 2001;40:1401–1409
  100. Kurz X. Dementia in Belgium: prevalence in aged patients consulting in general practice. Rev. Med. Liege. 2001;56(12):835–839Dec
  101. Landgren M, Pettersson R, Kjellman B, Gillberg C. ADHD, DAMP and other neurodevelopmental/psychiatric disorders in 6-year-old children: epidemiology and co-morbidity. Dev. Med. Child Neurol. 1996;38:891–906
  102. Larsson LG, Lindberg A, Franklin KA, Lundback B. Gender differences in symptoms related to sleep apnea in a general population and in relation to referral to sleep clinic. Chest. 2003;124(1):204–211Jul
  103. Latvala A, Tuulio-Henriksson A, Perälä J, Saarni S, Aalto-Setälä T, Aro H, et al. Prevalence and correlates of alcohol and other substance use disorders in young adulthood: a population-based study. BMC Psychiatry. 2009;9(9):73
  104. Leger D, Guilleminault C, Dreyfus JP, Delahaye C, Paillard M. Prevalence of insomnia in a survey of 12,778 adults in France. J. Sleep Res. 2000;9(1):35–42Mar
  105. Leger D, Partinen M, Hirshkowitz M, Chokroverty S, Hedner J. Characteristics of insomnia in a primary care setting: EQUINOX survey of 5293 insomniacs from 10 countries. Sleep Med. 2010;11(10):987–998Dec
  106. Leiknes K-A, Finset A, Moum T, Sandanger I. Current somatoform disorders in Norway: prevalence, risk factors and comorbidity with anxiety, depression and musculosketal disorders. Soc. Psychiatry Psychiatr. Epidemiol. 2007;42:698–710
  107. Leonardi M. Measuring health and disability: supporting policy development. The European MHADIE project. Disabil. Rehabil. 2010;32(Suppl. 1):S1–S8
  108. Leonardi M, Chatterji S, Ayuso-Mateos JL, Hollenweger J, Ustün B, Kostanjsek NF, et al. Integrating research into policy planning: MHADIE policy recommendations. Disabil. Rehabil. 2010;32(Suppl. 1):S139–S147
  109. *Lepine JP, Gastpar M, Mendlewicz J, Tylee A. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int. Clin. Psychopharmacol. 1997;12:19–29
  110. *Lieb R, Pfister H, Mastaler M, Wittchen H-U. Somatoform syndromes and disorders in a representative population sample of adolescents and young adults: prevalence, comorbidity and impairments. Acta Psychiatr. Scand. 2000;101:194–208
  111. Lieb R, Isensee B, von Sydow K, Wittchen H-U. The Early Developmental Stages of Psychopathology Study (EDSP): a methodological update. Eur. Addict. Res. 2000;6:170–182
  112. *Lindal E, Stefansson JG. The lifetime prevalence of anxiety disorders in Iceland as estimated by the US National Institute of Mental Health. Diagnostic Interview Schedule. Acta Psychiatr. Scand. 1993;88(1):29–34
  113. *Lindeman S, Hamalainen J, Isometsa E, Kaprio J, Poikolainen K, Heikkinen M, et al. The 12month prevalence and risk factors for major depressive episode in Finland: representative sample of 5993 adults. Acta Psychiatr. Scand. 2000;102:178–184
  114. Maercker A, Forstmeier S, Wagner B, Glaesmer H, Brahler E. Post-traumatic stress disorder in Germany. Results of a nationwide epidemiological study. Nervenarzt. 2008;79:577–586
  115. Maercker A, Forstmeier S, Enzler A, Krusi G, Horler E, Maier C, et al. Adjustment disorders, posttraumatic stress disorder, and depressive disorders in old age: findings from a community survey. Compr. Psychiatry. 2008;49:113–120
  116. Maulick PK, Mascarenhas MN, Mathers CD, Dua T, Saxena S. Prevalence of intellectual disability: a meta-analysis of population-based studies. Res. Dev. Disabil. 2011;32:419–436
  117. *McConnell P, Bebbington P, McClelland R, Gillespie K, Houghton S. Prevalence of psychiatric disorder and the need for psychiatric care in Nothern Ireland. Population study in the District of Derry. Br. J. Psychiatry. 2002;181:214–219
  118. McManus S, Meltzer H, Wesseley S. Posttraumatic stress disorder. In:  McManus S, et al. editor. Adult Psychiatric Morbidity in England 2007. NHS: The Health & Social Care Information Centre; 2009;
  119. In:  McManus S,  Meltzer H,  Brugha T,  Bebbington P,  Jenkins R editor. Adult Psychiatric Morbidity in England, 2007: Results of a Household Survey. The Health & Social Care Information Centre, Social Care Statistics; 2009;
  120. *Meyer C, Rumpf H-J, Hapke U, John U. Prevalence of DSM-IV psychiatric disorders including nicotine dependence in the general population: results from the northern German TACOS study. Neurol. Psychiatr. Br. 2001;9:75–80
  121. Moffitt TE, Caspi A, Taylor A, et al. How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment. Psychol. Med. 2010;40(6):899–909
  122. Murray CJ, Lopez AD. Evidence-based health policy — lessons from the Global Burden of Disease Study. Science. 1996;274:740–743
  123. NHS . The NHS Information Centre, Lifestyles Statistics: Statistics on Alcohol: Online. http://www.ic.nhs.uk/webfiles/publications/alcoholeng2009/Final%20Format%20draft%202009%20v72009;
  124. Nugent AM, Gleadhill I, McCrum E, Patterson CC, Evans A, MacMahon J. Sleep complaints and risk factors for excessive daytime sleepiness in adult males in Northern Ireland. J. Sleep Res. 2001;10(1):69–74Mar
  125. Ohayon MM, Bader G. Prevalence and correlates of insomnia in the Swedish population aged 19–75years. Sleep Med. 2010;11(10):980–986Dec
  126. Ohayon MM, Sagales T. Prevalence of insomnia and sleep characteristics in the general population of Spain. Sleep Med. 2010;11(10):1010–1018Dec
  127. Ohayon MM, Smirne S. Prevalence and consequences of insomnia disorders in the general population of Italy. Sleep Med. 2002;3(2):115–120Mar
  128. Ohayon MM, Guilleminault C, Priest RG, Caulet M. Snoring and breathing pauses during sleep: telephone interview survey of a United Kingdom population sample. BMJ. 1997;314(7084):860–863Mar 22
  129. Ohayon MM, Priest RG, Zulley J, Smirne S, Paiva T. Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology. 2002;58(12):1826–1833Jun 25
  130. Olesen J, Leonardi M. The burden of brain diseases in Europe. Eur. J. Neurol. 2003;10:471–477
  131. *Olsen J. Prevalence of major depression and stress indicators in the Danish general population. Acta Psychiatr. Scand. 2004;109:96–103
  132. Ott A, Breteler MM, van Harskamp F, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ. 1995;15:970–973
  133. Pakriev S, Vasar V, Aluoja A, Saarma M, Shlik J. Prevalence of mood disorders in the rural population of Udmurtia. Acta Psychiatr. Scand. 1998;97:169–174
  134. Pallesen S, Nordhus IH, Nielsen GH, Havik OE, Kvale G, Johnsen BH, et al. Prevalence of insomnia in the adult Norwegian population. Sleep. 2001;24(7):771–779Mar
  135. Perälä J, Suvisaari J, Saarni S, et al. Lifetime Prevalence of Psychotic and Bipolar I Disorders in a General Population. Arch. Gen. Psychiatry. 2007;64:19–28
  136. Philip P, Sagaspe P, Lagarde E, Leger D, Ohayon MM, Bioulac B, et al. Sleep disorders and accidental risk in a large group of regular registered highway drivers. Sleep Med. 2010;11(10):973–979Dec
  137. *Pirkola S, Isometsä E, Suvisaari J, Aro H, Joukamaa M, Poikolainen K, et al. DSM-IV mood-, anxiety and alcohol use disorders and their comorbidity in the Finnish general population. Results from the Health 2000 Study. Soc. Psych. Psych. Epid. 2005;40:1–10
  138. Plywaczewski R, Bednarek M, Jonczak L, Zielinski J. Sleep-disordered breathing in a middle-aged and older Polish urban population. J. Sleep Res. 2008;17(1):73–81Mar
  139. Preisig M, Waeber G, Vollenweider P, et al. The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors. BMC Psychiatry. 2009;9:9 doi:10.1186/1471-244X-9-9
  140. Preti A, Girolamo G, et al. The epidemiology of eating disorders in six European countries: results of the ESEMeD-WMH project. J. Psychiatr. Res. 2009;43(14):1125–1132
  141. Priebe S, Bogic M, Ajdukovic D, Franciskovic T, Galeazzi GM, et al. Mental disorders following war in the Balkans. Arch. Gen. Psychiatry. 2010;67:518–528
  142. Prince M, Patel V, Saxena S. No health without mental health. Lancet. 2007;9590:859–877
  143. Puura K, Almqvist F, Tamminen T, Piha J, Rasanen E, Kumpulainen K, et al. Psychiatric disturbances among prepubertal children in southern Finland. Soc. Psychiatry Psychiatr. Epidemiol. 1998;33:310–318
  144. Rahkonen . Dementia with Lewy bodies according to the consensus criteria in general population aged 75years or older. J. Neurol. Neurosurg. Psychiatry. 2003;74:720–724
  145. Rehm J, Room R, van den Brink W, Jacobi F. Alcohol use disorders in EU countries and Norway: an overview of the epidemiology. Eur. Neuropsychopharmacol. 2005;15(4):377–388
  146. Rehm J, Room R, van den Brink W, Kraus L. Problematic drug use and drug use disorders in EU countries and Norway: an overview of the epidemiology. Eur. Neuropsychopharmacol. 2005;15(4):389–397
  147. Riedel-Heller G. Prevalence of dementia according to DSM-III-R and ICD-10. Results of the Leipzig Longitudinal Study of the Aged (LEILA 75 +). Part 1. Br. J. Psychiatry. 2001;179:250–254
  148. Riedel-Heller S, Busse A, Angermeyer C. The state of mental health in old-age across the “old” European Union — a systematic review. Acta Psychiatrica Scandinavia. 2006;113:388–401
  149. Rice DP, Miller LS. Health economics and cost implications of anxiety and other mental disorders in the United States. Br. J. Psychiatr. 1998;173(Suppl. 34):4–9
  150. *Rihmer Z, Szadoczky E, Furedi J, Kiss K, Papp Z. Anxiety disorders comorbidty in bipolar I, bipolar II and unipolar major depression: results from a population-based study in Hungary. J. Affect. Disord. 2001;67:175–179
  151. Robins LN, Helzer JE, Croughan J, Ratcliff KS. National Institute of Mental Health Diagnostic Interview Schedule: its history, characteristics and validity. Arch. Gen. Psychiatry. 1981;38:381–389
  152. Robins LN, Wing J, Wittchen H-U, Helzer JE, Babor TF, Burke J, et al. The Composite International Diagnostic Interview: an epidemiological instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch. Gen. Psychiatry. 1988;45:1069–1077
  153. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. 3rd ed.. Philadelphia, USA: Lippincott, Williams & Wilkins; 2008;
  154. Salvador-Carulla L, Bertelli M. ‘Mental retardation’ or ‘intellectual disability’: time for a conceptual change. Psychopathology. 2008;41:10–16(+ original data from POMONA study)
  155. Salvador-Carulla, L., Reed, G.M., Vaez-Azizi, L.M., Cooper, S.A., Martinez-Leal, R., Bertelli, M., Adnams, C., Cooray, S., Deb, S., Akuory-Dirani, L., Girimaji, S.C., Katz, G., Kwok, H., Luckasson, R., Simeonsson, R., Walsh, C., Munir, K., Saxena, S., in press. Intellectual developmental disorders: towards a new name, definition and framework for “mental retardation/intellectual disability” in ICD-11. World Psychiatry, 10 (3).
  156. Saxena S, Thornicroft G, Knapp M, Whiteford H. Global Mental Health 2 — resources for mental health: scarcity, inequity, and inefficency. Lancet. 2007;370:878–889
  157. *Singleton N, Bumpstead R, O'Brien M, Lee A, Meltzer H. Psychiatric morbidity among adults living in private households. In: National Statistics. 154:London: The Stationery Office; 2001;
  158. Schalock RL, Luckasson RA, Shorgren KA. The Remaining of Mental Retardation: Understanding the Change to the Term Intellectual Disability. Intellect. Dev. Disabil. 2007;45(2):116–124
  159. Spijker J, de Graaf R, Bijl RV, Beekman ATF, Ormel J, Nolen WA. Functional disability and depression in the general population. Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Acta Psychiatr. Scand. 2004;110:208–214
  160. Stefánsson J-G, Líndal E. The prevalence of mental disorders in the Greater-Reykjavik area. Laeknabladid. 2009;95:559–564
  161. *Stefánsson J-G, Líndal E, Björnsson J-K, Guômundsdóttir Á. Lifetime prevalence of specific mental disorders among people born in Iceland in 1931. Acta Psychiatr. Scand. 1991;84:142–149
  162. Steinhausen H-C, Winkler MC, Meier M, Kannenberg R. Prevalence of child and adolescent psychiatric disorders: the Zürich Epidemiological Study. Acta Psychiatr. Scand. 1998;98:262–271
  163. Stouthard MEA, Essink-Bot ML, Bonsel GJ, Barendregt JJ, Kramer PG, van de Water HPA, et al. Disability Weights for Diseases in the Netherlands. Rotterdam: Erasmus University; 1997;
  164. Stradling JR, Crosby JH. Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. Thorax. 1991;46(2):85–90Feb
  165. Stradling JR, Barbour C, Glennon J, Langford BA, Crosby JH. Prevalence of sleepiness and its relation to autonomic evidence of arousals and increased inspiratory effort in a community based population of men and women. J. Sleep Res. 2000;9(4):381–388Dec
  166. *Szadoczky E, Papp Z, Vitrai J, Rihmer Z, Furedi J. The prevalence of major depressive and bipolar disorders in Hungary. J. Affect. Disord. 1998;50:153–162
  167. *Szadoczky E, Rihmer Z, Papp Z, Vitrai J, Füredi J. Gender differences in major depressive disorders in a Hungarian community survey. Int. J. Psychiatry. Clin. 2002;6:31–37
  168. Taylor E, Sandberg S. The Epidemiology of Childhood Hyperactivity. Oxford: Oxford University Press; 1991;
  169. Teculescu D, Mayeux L, Montaut-Verient B, Michaely JP, Mur JM. An epidemiologic study of sleep-disordered breathing in the male population of Lorraine: preliminary results. Sante Publique. 1998;10(2):177–190Jun
  170. ten Have M, de Graaf R, Vollebergh W, Beekman A. What depressive symptoms are associated with the use of care services? Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). J. Affect. Disord. 2004;80:239–248
  171. Tognoni G, Ceravolo R, Nucciarone B, et al. From mild cognitive impairment to dementia: a prevalence study in a district of Tuscany. Acta Neurol. Scand. 2005;112(2):65–71(Aug)
  172. Torgersen S, Kringlen E, Cramer V. The prevalence of personality disorders in a community sample. Arch. Gen. Psychiatry. 2001;58:590–596
  173. Torres AR, Prince MJ, et al. Obsessive-compulsive disorder: prevalence, comorbidity, impact, and help-seeking in the British National Psychiatric Morbidity Survey of 2000. Am. J. Psychiatry. 2006;163(11):1978–1985
  174. Tsolaki M, Fountoulakis C, Pavlopoulos I, et al. Prevalence and incidence of Alzheimer disease and other dementing disorders in Pylea, Greece. Am. J. Alzheimers Dis. Other Demen. 1999;14:138
  175. *Tylee A, Gastpar M, Lepine JP. Identification of depressed patient types in the community and their treatment needs: findings from the DEPRES II (Depression Research in European Society II). Survey. Int. Clin. Psychopharmacol. 1999;14:153–165
  176. Verhulst FC, van der Ende J, Kasius MC. The prevalence of DSMIII-R diagnoses in a national sample of Dutch adolescents. Arch. Gen. Psychiatry. 1997;54:326–329
  177. Vicente, J., Klempova, D., Matias, J., Olszewski D., Simon, R., 2010. Prevalence of intensive forms of cannabis use in the European Union and Norway. Unpublished manuscript.
  178. von Strauss E, Viitanen M, De Ronchi D, et al. Aging and the occurrence of dementia: findings from a population-based cohort with a large sample of nonagenarians. Arch. Neurol. 1999;56(5):587–592
  179. *Wacker H-R. Anxiety and Depression. An Epidemiological Investigation. Bern: Huber; 1995;
  180. WHO Euro. . European Status Report on Alcohol and Health 2010. Copenhagen: WHO Euro; 2010;
  181. Wing JK, Barbor T, Brugha T, Cooper JE, Giel R, Jablenski A, et al. SCAN: Schedules for Clinical Assessment in Neuropsychiatry. Arch. Gen. Psychiatry. 1990;47:589–593
  182. Wittchen H-U. Met and unmet need for interventions in community cases with anxiety disorders. In:  Andrews G,  Henderson S editor. Unmet Need in Psychiatry. Problems, Resources, Responses. Cambridge: Cambridge University Press; 2000;p. 256–276
  183. Wittchen H-U. Generalized anxiety disorder: prevalence, burden and cost to society. Depress. Anxiety. 2002;16:162–171
  184. Wittchen H-U, Jacobi F. Size and burden of mental disorders in Europe — a critical review and appraisal of 27 studies. Eur. Neuropsychopharmacol. 2005;15(4):357–376
  185. *Wittchen H-U, Essau C-A, von Zerssen D, Krieg J-C, Zaudig M. Lifetime and six-month prevalence of mental disorders in the Munich Follow-Up Study. Eur. Arch. Psychiatry Clin. Neurosci. 1992;241:247–258
  186. *Wittchen H-U, Nelson CB, Lachner G. Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychol. Med. 1998;28:109–126
  187. Wittchen HU, Krause P, Höfler M, Pittrow D, Winter S, Spiegel B, et al. NISAS-2000: the “Nationwide Insomnia Screening and Awareness Study”. Prevalence and interventions in primary care. Fortschr. Med. Orig. 2001;119(1):9–19
  188. Wittchen H-U, Jönsson B, Olesen J. Editorial: towards a better understanding of the size and burden and cost of brain disorders in Europe. Eur. Neuropsychopharmacol. 2005;15(4):355–356
  189. World Health Organisation . The World Health Report 2001 - Mental Health: New Understanding, New Hope. Geneva: WHO; 2001;
  190. World Health Organisation . World Health Report 2002. Reducing Risks, Promoting Healthy Life. Geneva: WHO; 2002;
  191. World Health Organisation . WHO Mental Health Atlas 2005 (Revised Edition). Mental Health: Evidence and Research. Department of Mental Health and Substance Abuse. Geneva: WHO; 2005;
  192. World Health Organisation . The Global Burden of Disease: 2004 Update. Geneva, Switzerland: WHO; 2008;
  193. World Health Organization . Tenth revision of the international classification of diseases, Chapter V (F): mental and behavioral disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organization; 1993;
  194. Zatonski W, Manczuk M, Sulkowska U HEM Project Team. Closing the health gap in the European Union. Warsaw, Poland: Cancer Epidemiology and Prevention Division, the Maria Sklodowska-Curie Memorial Cencer Center and Institute of Oncology; 2008;

PII: S0924-977X(11)00172-6

doi: 10.1016/j.euroneuro.2011.07.018

European Neuropsychopharmacology
Volume 21, Issue 9 , Pages 655-679 , September 2011