European Neuropsychopharmacology
Volume 20, Supplement 2 , Pages S105-S158, April 2010

Heroin-assisted treatment in the Netherlands: History, findings, and international context

  • Peter Blanken

      Affiliations

    • Central Committee on the Treatment of Heroin Addicts (CCBH), Utrecht, The Netherlands
    • Parnassia Addiction Research Center (PARC), The Hague, The Netherlands
    • Both authors contributed equally.
    • ,
  • Wim van den Brink

      Affiliations

    • Central Committee on the Treatment of Heroin Addicts (CCBH), Utrecht, The Netherlands
    • Amsterdam Institute for Addiction Research (AIAR) and Department of Psychiatry of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    • Both authors contributed equally.
    • Corresponding Author InformationCorresponding author. Academic Medical Center, Department of Psychiatry, PA1-188, P.O. Box 22660, 1100 DD Amsterdam, the Netherlands. Tel.: +31 020 8913634
    • ,
  • Vincent M. Hendriks

      Affiliations

    • Central Committee on the Treatment of Heroin Addicts (CCBH), Utrecht, The Netherlands
    • Parnassia Addiction Research Center (PARC), The Hague, The Netherlands
    • ,
  • Ineke A. Huijsman

      Affiliations

    • Central Committee on the Treatment of Heroin Addicts (CCBH), Utrecht, The Netherlands
    • ,
  • Marjolein G. Klous

      Affiliations

    • Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
    • ,
  • Elisabeth J. Rook

      Affiliations

    • Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
    • Netherlands Medicines Evaluation Board, The Hague, The Netherlands
    • ,
  • Jennifer S. Wakelin

      Affiliations

    • Wakelin Alliance, Zwartsluis, The Netherlands
    • ,
  • Cas Barendrecht

      Affiliations

    • IVO, Addiction Research Institute, Rotterdam and Department of Public Health, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    • ,
  • Jos H. Beijnen

      Affiliations

    • Department of Pharmacy and Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands
    • ,
  • Jan M. van Ree

      Affiliations

    • Central Committee on the Treatment of Heroin Addicts (CCBH), Utrecht, The Netherlands
    • Rudolf Magnus Institute of Neuroscience, Utrecht University Medical Center, Utrecht, The Netherlands

Summary

This monograph describes the history, findings and international context of heroin-assisted treatment (HAT) in the Netherlands. The monograph consists of (1) a short introduction and seven paragraphs describing the following aspects of HAT in the Netherlands: (2) history of HAT studies and implementation of routine HAT in the Netherlands; (3) main findings on efficacy, safety and cost-effectiveness from the two randomized controlled HAT trials in the Netherland; (4) new findings from a large cohort study on the effectiveness of HAT in routine clinical practice in the Netherlands; (5) unique data on the patient's perspective of HAT; (6) data on the pharmacological and pharmaceutical basis for HAT in the Netherlands; (7) description of the registration process; and (8) account of the international context of HAT. Together, these data show that HAT can now be considered a safe and proven-effective intervention for the treatment of chronic, treatment-resistant heroin dependent patients.

KEYWORDS:  Heroin , Drug dependence , Addiction Treatment Pharmacology , Effectiveness

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 The production of this monograph was sponsored by the Central Committee on the Treatment of Heroin Addicts (CCBH), installed and funded by the Netherlands Minister of Heath, Welfare and Sports (VWS).

PII: S0924-977X(10)70001-8

doi:10.1016/S0924-977X(10)70001-8

European Neuropsychopharmacology
Volume 20, Supplement 2 , Pages S105-S158, April 2010

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