Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system

Xu, Ying; Wang, Zhichao; You, Wenting; Zhang, Xiuhua; Li, Shan; Barish, Philip A.; Vernon, Matthew M.; Du, Xia; Li, Gaowen; Pan, Jianchun; Ogle, William O.

doi:10.1016/j.euroneuro.2010.02.013

« Previous Next »European Neuropsychopharmacology
Volume 20, Issue 6 , Pages 405-413, June 2010

Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system

Ying Xu
- J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, University of Florida, Gainesville, FL, 32611, USA
Zhichao Wang
- Department of Neurosurgery, Beijing Haidian Hospital, 29th Zhongguancun Street, Haidian District, Beijing, 100080, PR China
Wenting You
- Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, 325021, PR China
Xiuhua Zhang
- Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, 325021, PR China
Shan Li
- Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, 325021, PR China
Philip A. Barish
- J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, University of Florida, Gainesville, FL, 32611, USA
Matthew M. Vernon
- J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, University of Florida, Gainesville, FL, 32611, USA
Xia Du
- Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, 325021, PR China
Gaowen Li
- Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, 325021, PR China
Jianchun Pan
- Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, 325021, PR China
- Corresponding authors. Ogle is to be contacted at J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, Institute on Aging, University of Florida, Gainesville, FL 32611, USA. Tel.: +1 352 273 5877; fax: +1 352 392 9791. Pan, Tel.: +86 577 86689982; fax: +86 577 86689983.
William O. Ogle
- J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, University of Florida, Gainesville, FL, 32611, USA
- Corresponding authors. Ogle is to be contacted at J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, Institute on Aging, University of Florida, Gainesville, FL 32611, USA. Tel.: +1 352 273 5877; fax: +1 352 392 9791. Pan, Tel.: +86 577 86689982; fax: +86 577 86689983.

Received 24 November 2009; received in revised form 2 February 2010; accepted 26 February 2010. published online 31 March 2010.

Abstract

The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation.