European Neuropsychopharmacology
Volume 20, Issue 6 , Pages 421-425, June 2010

The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats

  • Martin Weber

      Affiliations

    • Department of Psychiatry, UCSD School of Medicine, USA
    • ,
  • Wei-Li Chang

      Affiliations

    • Department of Psychiatry, UCSD School of Medicine, USA
    • ,
  • Michelle R. Breier

      Affiliations

    • Department of Psychiatry, UCSD School of Medicine, USA
    • ,
  • Alex Yang

      Affiliations

    • Department of Psychiatry, UCSD School of Medicine, USA
    • ,
  • Mark J. Millan

      Affiliations

    • Institut de Recherches Servier, France
    • ,
  • Neal R. Swerdlow

      Affiliations

    • Department of Psychiatry, UCSD School of Medicine, USA
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr., La Jolla, CA 92093-0804, USA. Tel.: +1 619 543 6270; fax: +1 619 543 1801.

Received 25 November 2009; accepted 26 February 2010. published online 29 March 2010.

Abstract 

Dopamine agonists reduce prepulse inhibition (PPI) of startle in rats. While it is used to predict antipsychotic efficacy, the specific receptor subtypes mediating this effect of dopamine agonists remain unclear. We characterized the effects of sumanirole, a highly selective D2 agonist, on PPI in rats. Sumanirole decreased PPI at 60–120ms prepulse intervals, and increased PPI at 10–20ms intervals. PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI.

Keywords: Dopamine, D2 receptor, Prepulse inhibition, Schizophrenia, Sumanirole

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PII: S0924-977X(10)00044-1

doi:10.1016/j.euroneuro.2010.02.011

European Neuropsychopharmacology
Volume 20, Issue 6 , Pages 421-425, June 2010

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