Effects of chronic nicotine on food intake and anxiety-like behaviour in CB1 knockout mice
Received 18 November 2009; received in revised form 18 January 2010; accepted 3 February 2010. published online 02 March 2010.
Abstract
We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB1 knockout mice and wild-type littermates. Mutant mice showed lower levels of glucose, insulin and cholesterol after two weeks of high fat diet and reduced preference for saccharine solution when compared with wild-type mice. Nicotine reduced body weight and induced anxiogenic-like effects in wild-type, but not in CB1 knockout mice. Our results suggest a modulatory role of the endocannabinoid system on the effects induced by nicotine on metabolic parameters and anxiety-like responses.
Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB Barcelona, Spain
Corresponding author. Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB Barcelona, Spain, Dr. Aiguader 88, 08003 Barcelona, Spain. Tel.: +34 933160824; fax: +34 933160901.
ABSTRACT