European Neuropsychopharmacology
Volume 20, Issue 8 , Pages 545-552 , August 2010

Effect of hypertriglyceridemia on the pharmacokinetics and blood–brain barrier penetration of clozapine and norclozapine following administration to rats

  • Pavel Gershkovich

      Affiliations

    • Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    • Corresponding Author InformationCorresponding author. Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall Avenue, Vancouver, BC, Canada V6T 1Z3. Tel.: +1 604 822 6772; fax: +1 604 822 3035.
    • ,
  • Olena Sivak

      Affiliations

    • Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    • ,
  • Aishwariya Sharma

      Affiliations

    • Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    • ,
  • Alasdair M. Barr

      Affiliations

    • Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    • ,
  • Ric Procyshyn

      Affiliations

    • BC Mental Health and Addictions Research Institute, Vancouver, BC, Canada
    • ,
  • Kishor M. Wasan

      Affiliations

    • Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

Received 17 October 2009 ,Revised 31 December 2009 ,Accepted 21 January 2010.

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PII: S0924-977X(10)00018-0

doi: 10.1016/j.euroneuro.2010.01.002

European Neuropsychopharmacology
Volume 20, Issue 8 , Pages 545-552 , August 2010

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