European Neuropsychopharmacology
Volume 20, Issue 5 , Pages 317-326 , May 2010

Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule

  • C. Gelegen

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, Utrecht, The Netherlands
    • Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK
  • ,
  • E. Pjetri

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, Utrecht, The Netherlands
  • ,
  • I.C. Campbell

      Affiliations

    • Institute of Psychiatry, Department of Neuroscience, King's College London, UK
  • ,
  • D.A. Collier

      Affiliations

    • Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, UK
  • ,
  • H. Oppelaar

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, Utrecht, The Netherlands
  • ,
  • M.J.H. Kas

      Affiliations

    • Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Centre Utrecht, Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author. Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. Tel.: +31 88 756 8179; fax: +31 88 756 9032.

Received 12 June 2009 ,Revised 2 September 2009 ,Accepted 4 October 2009.

References 

  1. Adkins EC, Keel PK. Does “excessive” or “compulsive” best describe exercise as a symptom of bulimia nervosa?. Int. J. Eat. Disord. 2005;38:24–29
  2. American Psychiatric Association Work Group on Eating Disorders. Practice guideline for the treatment of patients with eating disorders (revision). Am. J. Psychiatry. 2000;157:1–39
  3. Bacanu SA, Bulik CM, Klump KL, Fichter MM, Halmi KA, Keel P, et al. Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariates. Am. J. Med. Genet. B., Neuropsychiatr. Genet. 2005;139B:61–68
  4. Belknap JK. Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mamm. Genome. 2003;14:723–732
  5. Bell MA, Travis MP. Hybridization, transgressive segregation, genetic covariation, and adaptive radiation. Trends Ecol. Evol. 2005;20:358–361
  6. Bennett B, Carosone-Link PJ, Lu L, Chesler EJ, Johnson TE. Genetics of body weight in the LXS recombinant inbred mouse strains. Mamm. Genome. 2005;16:764–774
  7. Beumont CC, Beumont PJV, Touyz SW. The problem of excessive physical activity in patients with anorexia nervosa. In:  Pierce WD,  Epling WE editor. In Activity Anorexia Theory, Research and Treatment. Lawrence Erlbaum Associates Inc; 1996;
  8. Brockmann GA, Kratzsch J, Haley CS, Renne U, Schwerin M, Karle S. Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice. Genome Res. 2000;10:1941–1957
  9. Brockmann GA, Tsaih SW, Neuschl C, Churchill GA, Li R. Genetic factors contributing to obesity and body weight can act through mechanisms affecting muscle weight, fat weight, or both. Physiol. Genomics. 2009;36:114–126
  10. Bulik CM, Sullivan PF, Tozzi F, Furberg H, Lichtenstein P, Pedersen NL. Prevalence, heritability, and prospective risk factors for anorexia nervosa. Arch. Gen. Psychiatry. 2006;63:305–312
  11. Bulik CM, Sullivan PF, Wade TD, Kendler KS. Twin studies of eating disorders: a review. Int. J. Eat. Disord. 2000;27:1–20
  12. Bulik CM, Sullivan PF, Weltzin TE, Kaye WH. Temperament in eating disorders. Int. J. Eat. Disord. 1995;17:251–261
  13. Carlborg O, Andersson L. Use of randomization testing to detect multiple epistatic QTLs. Genet. Res. 2002;79:175–184
  14. Carlborg O, Haley CS. Epistasis: too often neglected in complex trait studies?. Nat. Rev., Genet. 2004;5:618-6U4
  15. Carlsson S, Andersson T, Lichtenstein P, Michaelsson K, Ahlbom A. Genetic effects on physical activity: results from the Swedish Twin Registry. Med. Sci. Sports Exerc. 2006;38:1396–1401
  16. Carter JC, Blackmore E, Sutandar-Pinnock K, Woodside DB. Relapse in anorexia nervosa: a survival analysis. Psychol. Med. 2004;34:671–679
  17. Churchill GA. Recombinant inbred strain panels: a tool for systems genetics. Physiol. Genom. 2007;31:174–175
  18. Crawley JN, Belknap JK, Collins A, Crabbe JC, Frankel W, Henderson N, et al. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology (Berl.). 1997;132:107–124
  19. Dalle GR, Calugi S, Marchesini G. Compulsive exercise to control shape or weight in eating disorders: prevalence, associated features, and treatment outcome. Compr. Psychiatry. 2008;49:346–352
  20. Davis C, Kaptein S. Anorexia nervosa with excessive exercise: a phenotype with close links to obsessive–compulsive disorder. Psychiatry Res. 2006;142:209–217
  21. Davis C, Kaptein S, Kaplan AS, Olmsted MP, Woodside DB. Obsessionality in anorexia nervosa: the moderating influence of exercise. Psychosom. Med. 1998;60:192–197
  22. Davis C, Katzman DK, Kaptein S, Kirsh C, Brewer H, Kalmbach K, et al. The prevalence of high-level exercise in the eating disorders: etiological implications. Compr. Psychiatry. 1997;38:321–326
  23. Davis C, Katzman DK, Kirsh C. Compulsive physical activity in adolescents with anorexia nervosa: a psychobehavioral spiral of pathology. J. Nerv. Ment. Dis. 1999;187:336–342
  24. Davis C, Kennedy SH, Ralevski E, Dionne M, Brewer H, Neitzert C, et al. Obsessive compulsiveness and physical activity in anorexia nervosa and high-level exercising. J. Psychosom. Res. 1995;39:967–976
  25. Davis C, Woodside DB. Sensitivity to the rewarding effects of food and exercise in the eating disorders. Compr. Psychiatry. 2002;43:189–194
  26. Devicente MC, Tanksley SD. QTL analysis of transgressive segregation in an interspecific tomato cross. Genetics. 1993;134:585–596
  27. Duncan GE, Goldberg J, Noonan C, Moudon AV, Hurvitz P, Buchwald D. Unique environmental effects on physical activity participation: a twin study. PLoS ONE. 2008;3:e2019
  28. Eriksson M, Rasmussen F, Tynelius P. Genetic factors in physical activity and the equal environment assumption—the Swedish young male twins study. Behav. Genet. 2006;36:238–247
  29. Fawcett GL, Roseman CC, Jarvis JP, Wang B, Wolf JB, Cheverud JM. Genetic architecture of adiposity and organ weight using combined generation QTL analysis. Obesity. (Silver. Spring). 2008;16:1861–1868
  30. Fisch GS, Holmes A. Recent developments in the use of animal models of psychiatric disease—introduction to special issue. Behav. Genet. 2007;37:259–263
  31. Frank GK, Bailer UF, Henry SE, Drevets W, Meltzer CC, Price JC, et al. Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride. Biol. Psychiatry. 2005;58:908–912
  32. Gelegen C, Collier DA, Campbell IC, Oppelaar H, Kas MJ. Behavioral, physiological, and molecular differences in response to dietary restriction in three inbred mouse strains. Am. J. Physiol. Endocrinol. Metab. 2006;291:E574–E581
  33. Gelegen C, Collier DA, Campbell IC, Oppelaar H, van den HJ, Adan RA, et al. Difference in susceptibility to activity-based anorexia in two inbred strains of mice. Eur. Neuropsychopharmacol. 2007;17:199–205
  34. Gelegen C, van den HJ, Collier DA, Campbell IC, Oppelaar H, Hessel E, et al. Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule. Genes Brain Behav. 2008;7:552–559
  35. Gharavi AG, Ahmad T, Wong RD, Hooshyar R, Vaughn J, Oller S, et al. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc. Natl Acad. Sci. USA. 2004;101:2488–2493
  36. Gill K, Boyle A, Lake K, Desaulniers N. Alcohol-induced locomotor activation in C57BL/6J, A/J, and AXB/BXA recombinant inbred mice: strain distribution patterns and quantitative trait loci analysis. Psychopharmacology (Berl.). 2000;150:412–421
  37. Grange DL, Eisler I. The link between anorexia nervosa and excessive exercise: a review. Eur. Eat. Disord. Rev. 1993;1(2):100–119
  38. Grice DE, Halmi KA, Fichter MM, Strober M, Woodside DB, Treasure JT, et al. Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. Am. J. Hum. Genet. 2002;70:787–792
  39. Hebebrand J, Casper R, Treasure J, Schweiger U. The need to revise the diagnostic criteria for anorexia nervosa. J. Neural Transm. 2004;111:827–840
  40. Hessel EV, van Gassen KL, Wolterink-Donselaar IG, Stienen PJ, Fernandes C, Brakkee JH, et al. Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility. Genes Brain Behav. 2009;8:248–255
  41. Hill AE, Lander ES, Nadeau JH. Chromosome substitution strains: a new way to study genetically complex traits. Methods Mol. Med. 2006;128:153–172
  42. Hoek HW. Incidence, prevalence and mortality of anorexia nervosa and other eating disorders. Curr. Opin. Psychiatry. 2006;19:389–394
  43. Holtkamp K, Hebebrand J, Herpertz-Dahlmann B. The contribution of anxiety and food restriction on physical activity levels in acute anorexia nervosa. Int. J. Eat. Disord. 2004;36:163–171
  44. Kas MJ, de Mooij-van Malsen AJ, Olivier B, Spruijt BM, van Ree JM. Differential genetic regulation of motor activity and anxiety-related behaviors in mice using an automated home cage task. Behav. Neurosci. 2008;122:769–776
  45. Kas MJ, Gelegen C, Schalkwyk LC, Collier DA. Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry. Am. J. Med. Genet. B., Neuropsychiatr. Genet. 2009;150B(3):309–317
  46. Kas MJ, de Mooij-van Malsen JG, de Krom M, van Gassen KL, van Lith HA, Olivier B, et al. High-resolution genetic mapping of mammalian motor activity levels in mice. Genes Brain Behav. 2009;8:13–22
  47. Kas MJ, Kaye WH, Foulds MW, Bulik CM. Interspecies genetics of eating disorder traits. Am. J. Med. Genet. B., Neuropsychiatr. Genet. 2009;150B:318–327
  48. Kaye WH, Bulik CM, Thornton L, Barbarich N, Masters K. Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am. J. Psychiatry. 2004;161:2215–2221
  49. Kirk EP, Hyun C, Thomson PC, Lai D, Castro ML, Biben C, et al. Quantitative trait loci modifying cardiac atrial septal morphology and risk of patent foramen ovale in the mouse. Circ. Res. 2006;98:651–658
  50. Klein DA, Bennett AS, Schebendach J, Foltin RW, Devlin MJ, Walsh BT. Exercise “addiction” in anorexia nervosa: model development and pilot data. CNS. Spectr. 2004;9:531–537
  51. Kortegaard LS, Hoerder K, Joergensen J, Gillberg C, Kyvik KO. A preliminary population-based twin study of self-reported eating disorder. Psychol. Med. 2001;31:361–365
  52. Koza RA, Hohmann SM, Guerra C, Rossmeisl M, Kozak LP. Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. Obes. Res. 2000;8:59S
  53. Lauderdale DS, Fabsitz R, Meyer JM, Sholinsky P, Ramakrishnan V, Goldberg J. Familial determinants of moderate and intense physical activity: a twin study. Med. Sci. Sports Exerc. 1997;29:1062–1068
  54. Maia JA, Thomis M, Beunen G. Genetic factors in physical activity levels: a twin study. Am. J. Prev. Med. 2002;23:87–91
  55. Mangweth B, Hudson JI, Pope HG, Hausmann A, De Col C, Laird NM, et al. Family study of the aggregation of eating disorders and mood disorders. Psychol. Med. 2003;33:1319–1323
  56. Matin A, Collin GB, Asada Y, Varnum D, Nadeau JH. Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain. Nat. Genet. 1999;23:237–240
  57. Mooij-van Malsen JG, van Lith HA, Oppelaar H, Olivier B, Kas MJH. Evidence for epigenetic interactions for loci on mouse chromosome 1 regulating open field activity. Behav. Genet. 2009;39:176–182
  58. Nadeau JH, Singer JB, Matin A, Lander ES. Analysing complex genetic traits with chromosome substitution strains. Nat. Genet. 2000;24:221–225
  59. O'Brien KM, Vincent NK. Psychiatric comorbidity in anorexia and bulimia nervosa: nature, prevalence, and causal relationships. Clin. Psychol. Rev. 2003;23:57–74
  60. Papadopoulos FC, Ekbom A, Brandt L, Ekselius L. Excess mortality, causes of death and prognostic factors in anorexia nervosa. Br. J. Psychiatry. 2009;194:10–17
  61. Penas-Lledo E, Vaz Leal FJ, Waller G. Excessive exercise in anorexia nervosa and bulimia nervosa: relation to eating characteristics and general psychopathology. Int. J. Eat. Disord. 2002;31:370–375
  62. Ponder CA, Munoz M, Gilliam TC, Palmer AA. Genetic architecture of fear conditioning in chromosome substitution strains: relationship to measures of innate (unlearned) anxiety-like behavior. Mamm. Genome. 2007;18:221–228
  63. Prpic V, Watson PM, Frampton IC, Sabol MA, Jezek GE, Gettys TW. Differential mechanisms and development of leptin resistance in A/J versus C57BL/6J mice during diet-induced obesity. Endocrinology. 2003;144:1155–1163
  64. Rieseberg LH, Archer MA, Wayne RK. Transgressive segregation, adaptation and speciation. Heredity. 1999;83:363–372
  65. Schebendach JE, Klein DA, Foltin RW, Devlin MJ, Walsh BT. Relative reinforcing value of exercise in inpatients with anorexia nervosa: model development and pilot data. Int. J. Eat. Disord. 2007;40:446–453
  66. Seong E, Seasholtz AF, Burmeister M. Mouse models for psychiatric disorders. Trends Genet. 2002;18:643–650
  67. Shao H, Burrage LC, Sinasac DS, Hill AE, Ernest SR, O'Brien W, et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc. Natl. Acad. Sci. U. S. A. 2008;105:19910–19914
  68. Shockley KR, Churchill GA. Gene expression analysis of mouse chromosome substitution strains. Mamm. Genome. 2006;17:598–614
  69. Shroff H, Reba L, Thornton LM, Tozzi F, Klump KL, Berrettini WH, et al. Features associated with excessive exercise in women with eating disorders. Int. J. Eat. Disord. 2006;39:454–461
  70. Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, et al. Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 2004;304:445–448
  71. Singer JB, Hill AE, Nadeau JH, Lander ES. Mapping quantitative trait loci for anxiety in chromosome substitutions strains of mice. Genetics. 2005;169:855–862
  72. Strober M, Freeman R, Lampert C, Diamond J, Kaye W. Controlled family study of anorexia nervosa and bulimia nervosa: evidence of shared liability and transmission of partial syndromes. Am. J. Psychiatry. 2000;157:393–401
  73. Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, et al. Genetic influences on exercise participation in 37, 051 twin pairs from seven countries. PLoS ONE. 2006;1:e22
  74. Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA. Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm. Genome. 2006;17:22–36
  75. Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC, et al. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism. 1995;44:645–651
  76. Takada T, Mita A, Maeno A, Sakai T, Shitara H, Kikkawa Y, et al. Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Genome Res. 2008;18:500–508
  77. Thifault S, Lalonde R, Sanon N, Hamet P. Comparisons between C57BL/6J and A/J mice in motor activity and coordination, hole-poking, and spatial learning. Brain Res. Bull. 2002;58:213–218
  78. Thome JL, Espelage DL. Obligatory exercise and eating pathology in college females: replication and development of a structural model. Eat. Behav. 2007;8:334–349
  79. van Gaalen MM, Steckler T. Behavioural analysis of four mouse strains in an anxiety test battery. Behav. Brain Res. 2000;115:95–106
  80. Winawer MR, Kuperman R, Niethammer M, Sherman S, Rabinowitz D, Guell IP, et al. Use of chromosome substitution strains to identify seizure susceptibility loci in mice. Mamm. Genome. 2007;18:23–31
  81. Yi N, Xu S, Allison DB. Bayesian model choice and search strategies for mapping interacting quantitative trait loci. Genetics. 2003;165:867–883
  82. Youngren KK, Nadeau JH, Matin A. Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications. Hum. Mol. Genet. 2003;12:389–398

PII: S0924-977X(09)00237-5

doi: 10.1016/j.euroneuro.2009.10.001

European Neuropsychopharmacology
Volume 20, Issue 5 , Pages 317-326 , May 2010