European Neuropsychopharmacology
Volume 13, Issue 5 , Pages 355-363 , October 2003

Antinociceptive effects of tricyclic antidepressants and their noradrenergic metabolites

,Accepted 14 January 2003.

References 

  1. Abbott FV, Melzack R, Samuel C. Morphine analgesia in tail-flick and formalin pain tests is mediated by different neural systems. Exp. Neurol. 1982;75:644–651
  2. Aigner M, Bach M. The antinociceptive effect of antidepressants—noradrenergic versus serotonergic modes of action?. Pain. 2000;88:217–218
  3. Ardid D, Marty H, Fialip J, Privat AM, Eschalier A, Lavarenne J. Comparative effects of different uptake inhibitor antidepressants in two pain tests in mice. Fundam. Clin. Pharmacol. 1992;6:75–82
  4. Atkinson JH, Slater MA, Wahlgren DR, Williams RA, Zisook S, Pruitt SD, et al. Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity. Pain. 1999;83:137–145
  5. Bardin L, Lavarenne J, Eschalier A. Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats. Pain. 2000;86:11–18
  6. Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 1984;7:309–338
  7. Bohn LM, Xu F, Gainetdinov RR, Caron MG. Potentiated opioid analgesia in norepinephrine transporter knock-out mice. J. Neurosci. 2000;20:9040–9045
  8. Borsini F, Bendotti C, Velkov V, Rech R, Samanin R. Immobility test: effects of 5-hydroxytryptaminergic drugs and role of catecholamines in the activity of some antidepressants. J. Pharm. Pharmacol. 1981;33:33–37
  9. Bowker RM, Abbott LC. Quantitative re-evaluation of descending serotonergic and non-serotonergic projections from the medulla of the rodent: evidence for extensive co-existence of serotonin and peptides in the same spinally projecting neurons, but not from the nucleus raphe magnus. Brain Res. 1990;512:15–25
  10. Bryson HM, Wilde MI. Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states. Drugs Aging. 1996;8:459–476
  11. Carlsson A, Corrodi H, Fuxe K, Hokfelt T. Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4-alpha-dimethyl-meta-tyramine. Eur. J. Pharmacol. 1969;5:367–373
  12. Casas J, Gibert-Rahola J, Chover AJ, Micó JA. Test-dependent relationship of the antidepressant and analgesic effects of amitriptyline. Methods Find. Exp. Clin. Pharmacol. 1995;17:583–588
  13. Casas J, Gibert-Rahola J, Valverde O, Tejedor-Real P, Romero P, Micó JA. Antidepressants, is there a correlation between their analgesic and antidepressant effect?. Eur. Neuropsychopharmacol. 1993;3:343–344
  14. Collins SL, Moore RA, McQuay HJ, Wiffen P. Antidepressants and anticonvulsants for diabetic neuropathy and postherapeutic neuralgia: a quantitative systematic review. J. Pain Symptom Manage. 2000;20:449–458
  15. D’Amour FE, Smith DL. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 1941;72:74–79
  16. De Angelis L. ‘Newer’ versus ‘older’ antidepressant drugs in the treatment of chronic pain syndromes. Adv. Ther. 1992;9:91–97
  17. De Gandarias JM, Irazusta J, Varona A, Gil J, Fernandez D, Casis L. Effect of imipramine on enkephalin-degrading peptidases. Eur. Neuropsychopharmacol. 1999;9:493–499
  18. Dennis SG, Melzack R, Gutman S, Boucher F. Pain modulation by adrenergic agents and morphine as measured by three pain tests. Life Sci. 1980;26:1247–1259
  19. Dirksen R, Van Diejen D, Van Luijtelaar EL, Booij LH. Site- and test-dependent antinociceptive efficacy of amitriptyline in rats. Pharmacol. Biochem. Behav. 1994;47:21–26
  20. Dirksen R, Van Luijtelaar EL, Van Rijn CM. Selective serotonin reuptake inhibitors may enhance responses to noxious stimulation. Pharmacol. Biochem. Behav. 1998;60:719–725
  21. Dubuisson D, Dennis G. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine and brain stem stimulation in rats and cats. Pain. 1977;4:161–174
  22. Eschalier A, Ardid D, Coudore F. Pharmacological studies of the analgesic effect of antidepressants. Clin. Neuropharmacol. 1992;15:373A–374A
  23. Eschalier A, Montastruc JL, Devoize JL, Rigal F, Gaillard-Plaza G, Pechadre JC. Influence of naloxone and methylsergide on the analgesic effect of clomipramine in rats. Eur. J. Pharmacol. 1981;74:1–7
  24. Hamon M, Gozlan H, Bourgoin S, Benoliel JJ, Mauborgne A, Taquet H, et al. Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline. Neuropharmacology. 1987;26:531–539
  25. Hyttel J. Citalopram—pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog. Neuropsychopharmacol. Biol. Psychiatry. 1982;6:277–295
  26. Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin reuptake inhibitors for the management of chronic pain. J. Gen. Intern. Med. 1997;12:384–389
  27. Korzeniewska-Rybicka I, Plaznik A. Analgesic effect of antidepressant drugs. Pharmacol. Biochem. Behav. 1998;59:331–338
  28. Koster R, Anderson M, Debeer EJ. Acetic acid for analgesia screening. Fed. Proc. 1959;18:412
  29. Magni G. The use of antidepressants in the treatment of chronic pain. A review of the current evidence. Drugs. 1991;42:730–748
  30. Magni G, Conlon P, Arsie D. Tricyclic antidepressants in the treatment of cancer pain: a review. Pharmacopsychiatry. 1987;20:160–164
  31. Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N. Engl. J. Med. 1992;326:1250–1256
  32. McFarlane J, Jalai S, Grace E. Trimipramine in rheumatoid arthritis: a randomized double-blind trial in relieving pain and joint tenderness. Curr. Med. Res. Opin. 1986;10:89–93
  33. McQuay HJ, Tramer M, Nye BA, Carroll D, Wiffen PJ, Moore RA. A systematic review of antidepressants in neuropathic pain. Pain. 1996;68:217–227
  34. Micó JA, Gibert-Rahola J, Casas J, Rojas O, Serrano MI, Serrano JS. Implication of beta 1- and beta 2-adrenergic receptors in the antinociceptive effect of tricyclic antidepressants. Eur. Neuropsychopharmacol. 1997;7:139–145
  35. Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, Raber P, et al. Heritability of nociception II. ‘Types’ of nociception revealed by genetic correlation analysis. Pain. 1999;80:83–93
  36. Morello CM, Leckband SG, Stoner CP, Moorhouse DF, Sahagian GA. Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain. Arch. Intern. Med. 1999;159:1931–1937
  37. O’Malley PG, Balden E, Tomkins G, Santoro J, Kroenke K, Jackson JL. Treatment of fibromyalgia with antidepressants. A meta-analysis. J. Gen. Intern. Med. 2000;15:659–666
  38. Onghena P, Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies. Pain. 1992;49:205–219
  39. Ortega-Alvaro A, Gibert-Rahola J, Mellado-Fernandez ML, Chover AJ, Micó JA. The effects of different monoaminergic antidepressants on the analgesia induced by spinal cord adrenal medullary transplants in the formalin test in rats. Anesth. Analg. 1997;84:816–820
  40. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 1978;47:379–391
  41. Porsolt RD, Bertin A, Blavet N, Jalfre M. Immobility induced by forced swimming in rats: effect of agents which modify central catecholamine and serotonin activity. Eur. J. Pharmacol. 1979;57:201–210
  42. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 1977;229:327–336
  43. Rojas-Corrales MO, Gibert-Rahola J, Micó JA. Tramadol induces antidepressant-type effects in mice. Life Sci. 1998;63:PL175–PL180
  44. Rojas-Corrales MO, Ortega-Alvaro A, Gibert-Rahola J, Roca-Vinardell A, Mico JA. Pindolol, a beta-adrenoceptor blocker/5-hydroxytryptamine(1A/1B) antagonist, enhances the analgesic effect of tramadol. Pain. 2000;88:119–124
  45. Sacerdote P, Brini A, Mantegazza P, Panerai AE. A role for serotonin and beta-endorphin in the analgesia induced by some tricyclic antidepressant drugs. Pharmacol. Biochem. Behav. 1987;26:153–158
  46. Schmauss C, Emrich HM. Narcotic antagonist and opioid treatment in psychiatry. In:  Rogers RJ,  Cooper SJ editor. Endorphins, Opiates and Behavioral Processes. New Delhi: Wiley; 1988;p. 327–351
  47. Semba JI, Takahashi R. Effect of monoamine precursors on the forced-swimming test in mice. Psychopharmacology. 1988;95:222–225
  48. Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action. Pain. 1999;83:389–400
  49. Sindrup SH, Jensen TS. Pharmacologic treatment of pain in polyneuropathy. Neurology. 2000;55:915–920
  50. Spenger C, Josephson A, Klason T, Hoehn M, Schwindt W, Ingvar M, et al. Functional MRI at 4.7 tesla of the rat brain during electric stimulation of forepaw, hindpaw, or tail in single- and multislice experiments. Exp. Neurol. 2000;166:246–253
  51. Spiegel K, Kalb R, Pasternak GW. Analgesic activity of tricyclic antidepressants. Ann. Neurol. 1983;13:462–465
  52. Sulser F, Mobley PL. Biochemical effects of antidepressants in animals. In:  Hoffmeister F,  Stile G editor. Psychotropic Agents. Part I: Antipsychotics and Antidepressants. Berlin: Springer-Verlag; 1980;p. 471–490
  53. Tura B, Tura SM. The analgesic effect of tricyclic antidepressants. Brain Res. 1990;518:19–22
  54. Valverde O, Micó JA, Maldonado R, Mellado ML, Gibert-Rahola J. Participation of opioid and monoaminergic mechanisms on the antinociceptive effect induced by tricyclic antidepressants in two behavioral pain test in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry. 1994;18:1073–1092
  55. Walsh TD. Antidepressants in chronic pain. Clin. Neuropharmacol. 1983;6:271–295
  56. Woolfe HG, Macdonald AD. The evaluation of the analgesic action of pethidine hydrochloride. J. Pharmacol. Exp. Ther. 1944;80:300–307
  57. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain. 1983;16:109–110

PII: S0924-977X(03)00017-8

doi: 10.1016/S0924-977X(03)00017-8

European Neuropsychopharmacology
Volume 13, Issue 5 , Pages 355-363 , October 2003