European Neuropsychopharmacology
Volume 13, Issue 5 , Pages 321-325 , October 2003

Ginkgo biloba normalises stress-elevated alterations in brain catecholamines, serotonin and plasma corticosterone levels

Received 20 April 2002 ,Accepted 10 January 2003.

References 

  1. Andrews G, Sanderson K, Slade T, Isakidis C. Why does the burden of disease persist? Relating the burden of anxiety and depression to effectiveness of treatment. Bull. World Health Organ. 2000;78(4):446–454
  2. Bastianetto S, Zheng W, Quirion R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. J. Neurochem. 2000;74:2268–2277
  3. Bhattacharyya SK, Bhattacharyya D. Effect of restraint stress on rat brain serotonin. J. Biosci. 1982;4:269–274
  4. Bhattacharyya D, Sur TK. The effect of Panax ginseng and diazepam on norepinephrine levels of whole brain and hypothalamus during stress. Indian J. Pharmacol. 1999;31:124–127
  5. Chen X, Salwinski S, Lee TJ. Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clin. Exp. Pharmacol. Physiol. 1997;24:958–959
  6. Chrousos GP, Gold PW. The concepts of stress and stress system disorders: Overview of physical and behavioural homeostasis. J. Am. Med. Assoc. 1992;267:1244–1252
  7. Clostre F. Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000. Ann. Pharm. Fr. 1999;57(Suppl. 1):IS8–88
  8. Curtis-Prior P, Vere D, Fray P. Therapeutic value of Ginkgo biloba in reducing symptoms of decline in mental function. J. Pharm. Pharmacol. 1999;51:535–541
  9. Fitzl G, Welt K, Martin R, Dettmer D, Hermsdorf T, Clemens N, et al. The influence of hypoxia on the myocardium of experimentally diabetic rats with and without protection by Ginkgo biloba extract. I. Ultrastructural and biochemical investigations on cardiomyocytes. Exp. Toxicol. Pathol. 2000;52(5):419–430
  10. Guidetti C, Paracchini S, lucchinin S, Cambieri M, Marzatico F. Prevention of neuronal cell damage induced by oxidative stress in-vitro: effect of different Ginkgo biloba extracts. J. Pharm. Pharmacol. 2001;53(3):387–392
  11. Hoyer S, Lannert H, Noldner M, Chatterjee SS. Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761). J. Neural Transm. 1999;106:1171–1188
  12. Imam Z, Newport GD, Islam F, Slikker W, Ali SF. Selenium; an antioxidant, protects against methamphetamine induced dopaminergic neurotoxicity. Brain Res. 1999;818:515–578
  13. Jones MT, Gillham B, Cambell EA, Al-Tahir ARH, Chung TT, Disciullo A. Pharmacology of neural pathways affecting CRH secretion. Ann. NY Acad. Sci. 1988;512:162–175
  14. Kanowski S, Herrmann WM, Stephan K, et al.  Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatient suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychology. 1996;29:47–56
  15. Klein J, Chatterjee SS, Loffelholz K. Phospholipid breakdown and choline release under hypoxic conditions: inhibition by bilobalide, a constituent of Ginkgo biloba. Brain Res. 1997;755:347–350
  16. Lundberg U. Catecholamines. In:  George F editors. Encyclopedia of Stress. Academic Press; 2000;p. 408–511
  17. Maitra I, Marcocci L, Droy-Lefaix MT, Packer L. Peroxyl radical scavenging activity of Ginkgo biloba extract EGb 761. Biochem. Pharmacol. 1995;49:1649–1655
  18. Marcilhac A, Dakine N, Bourhim N, Guillaume V, Grino M, Drieu K, et al. Effect of chronic administration of Ginkgo biloba extract or Ginkgolide on the hypothalamic–pituitary–adrenal axis in the rat. Life Sci. 1998;62(25):2329–2340
  19. Mattingly D. A simple fluorimetric method for the estimation of free 11-hydroxycorticosteroids in human plasma. J. Clin. Pathol. 1962;15:374–379
  20. McIntosh KT, Thomas Y, Gennarelli TA. Alterations in regional brain catecholamine concentrations after experimental brain injury in the rat. J. Neurochem. 1994;63:1426–1433
  21. Oyama Y, Chikahisa L, Ueha T, Kanemaru K, Noda K. Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Res. 1996;712(12):349–352
  22. Pacak K, Palkovits M, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary adrenocortical and sympathoadrenal activity: in vivo microdialysis studies. Front. Neuroendocrinol. 1995;16:89–150
  23. Pietri S, Maurelli E, Drieu K, Culcasi M. Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761). J. Mol. Cell Cardiol. 1997;29:733–742
  24. Plotsky PM, Cunninghum ET, Widmaier EP. Catecholaminergic modulation of corticotrophin releasing factor and adrenocorticotrophin secretion. Endocr. Rev. 1989;10:4437–4458
  25. Pol O, Campmany L, Armario A. Inhibition of catecholamine synthesis with α-methyl-p-tyrosine apparently increases brain serotoninergic activity in the rat: No influence of previous chronic immobilization stress. Pharmacol. Biochem. Behav. 1995;52:107–112
  26. Robert OP, Fawzy IF. Stress and psychiatry. In:  Harald IK,  Benjamin JS editor. 5th Edition. Comprehensive Text Book of Psychiatry. Vol. 2:Baltimore, MD: Williams and Wilkins; 1989;p. 3–11
  27. Shen JG, Zhou DY. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochem. Mol. Biol. Int. 1995;35:125–134
  28. Smith PF, Maclennan K, Darlington CL. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J. Ethnopharmacol. 1996;50:131–139
  29. Stanwood GD, Zigmond MJ. Dopamine, Central. In:  George F editors. Encyclopedia of Stress. Academic Press; 2000;p. 408–511
  30. Steinhauer HB, Anhut H, Hertting G. Stress induced increase of prostaglandin synthesis in mouse brain. In:  Usdin E,  Kvetnansky R,  Kopin IJ editor. Catecholamines and Stress. New York: Elsevier/North-Holland; 1980;p. 101–106
  31. Sur TK, Bhattacharyya D. Effect of Panax ginseng and diazepam on brain and hypothalamic 5-hydroxytryptamine during stress. Indian J. Pharmacol. 1997;29:318–321
  32. Szabo ME, Droy-Lefaix MT, Doly M, Braquet P. Modification of ischemia/reperfusion-induced ion shifts (Na+, K+, Ca2+ and Mg2+) by free radical scavengers in the rat retina. Ophthalmic Res. 1993;25:1–9
  33. Szafarczyk A, Ixart G, Gaillet S, Siaud P, Barbanel G, Malaval F, et al. Stress. Neuropharmacologic studies. Encephale. 1993;1:137–142
  34. Youdim KA, Joseph JA. A possible emerging role of phytochemicals in improving age-related neurological dysfunction: a multiplicity of effects. Free Radic. Biol. Med. 2001;30(6):583–594

PII: S0924-977X(03)00005-1

doi: 10.1016/S0924-977X(03)00005-1

European Neuropsychopharmacology
Volume 13, Issue 5 , Pages 321-325 , October 2003